The potential of the stem cells composite hydrogel wound dressings for promoting wound healing and skin regeneration: In vitro and in vivo evaluation

In this study, the wound healing properties of the gelatin-based hydrogel (GBH) wound dressing combined with adipose-derived stem cells (ADSCs) were investigated using the mouse and porcine models. The analytical results showed that the ADSCs harvested from the porcine significantly increased cell g...

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Published inJournal of biomedical materials research. Part B, Applied biomaterials Vol. 107; no. 2; pp. 278 - 285
Main Authors Hsu, Ling-Chuan, Peng, Bou-Yue, Chen, May-Show, Thalib, Bahruddin, Ruslin, Muhammad, Tung, Tran Dang Xuan, Chou, Hsin-Hua, Ou, Keng-Liang
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.02.2019
Subjects
Adipogenesis
Alternative medicine
Animal models
Biocompatibility
Biomedical materials
Cell culture
Cell differentiation
Differentiation (biology)
Gelatin
Hydrogels
In vivo methods and tests
Materials research
Materials science
Medical dressings
Osteogenesis
Regeneration
Skin
Skin injuries
Stem cell transplantation
Stem cells
Wound healing
adipose-derived stem cells
wound healing
hydrogel
skin regeneration
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Summary:In this study, the wound healing properties of the gelatin-based hydrogel (GBH) wound dressing combined with adipose-derived stem cells (ADSCs) were investigated using the mouse and porcine models. The analytical results showed that the ADSCs harvested from the porcine significantly increased cell growth and promoted cell differentiation (adipogenesis and osteogenesis) in comparison to the ADSCs harvested from the mouse in vitro. Moreover, the in vivo results also indicated that the GBH wound dressing combined with ADSCs and its culture medium could potentially accelerate wound healing in the mouse and porcine models. The ADSCs presented a possibility of recovery from wounds and injuries through skin regeneration. Therefore, both in vitro and in vivo results demonstrated that the ADSCs can potentially be an effective clinical treatment through the GBH wound dressing, which is a promising evidence-based complementary and alternative medicine for skin regeneration. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 278-285, 2019.
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ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.34118