Nuclear Factor One X Regulates Bobby Sox During Development of the Mouse Forebrain

• Published in: Cellular and molecular neurobiology Vol. 33; no. 7; pp. 867 - 873
• Main Authors: Dixon, Chantelle, Harvey, Tracey J., Smith, Aaron G., Gronostajski, Richard M., Bailey, Timothy L., Piper, Michael
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.10.2013
• Subjects: Animals; Base Sequence; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cortex; Hippocampus - cytology; Hippocampus - metabolism; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Neurobiology; Neurosciences; NFI Transcription Factors - metabolism; Promoter Regions, Genetic - genetics; Prosencephalon - cytology; Prosencephalon - embryology; Prosencephalon - metabolism; Short Communication; Trans-Activators - metabolism; Transcription, Genetic; Up-Regulation; Transcription factor; Nuclear factor one X; Bobby sox; Neural progenitor cell
• ISSN: 0272-4340; 1573-6830
• DOI: 10.1007/s10571-013-9961-4

The transcription factor nuclear factor one X (NFIX) plays a central role during the development of the neocortex and hippocampus, through the activation of astrocyte-specific gene expression and the repression of progenitor-specific pathways. However, our understanding of transcriptional targets of NFIX during cortical development remains limited. Here, we identify the transcription factor Bobby sox (Bbx) as a target for NFI-mediated transcriptional control. BBX is expressed within ventricular zone progenitor cells within the developing neocortex and hippocampus, and its expression is upregulated in Nfix − / − mice. Moreover, we reveal that NFIX can repress Bbx promoter-driven expression. Collectively, these data suggest that Bbx is a downstream target of NFIX during development of the forebrain.