Fat and inflammation: adipocyte-myeloid cell crosstalk in atherosclerosis

Adipose tissue inflammation has been implicated in various chronic inflammatory diseases and cancer. Perivascular adipose tissue (PVAT) surrounds the aorta as an extra layer and was suggested to contribute to atherosclerosis development. PVAT regulates the function of endothelial and vascular smooth...

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Published inFrontiers in immunology Vol. 14; p. 1238664
Main Authors Mazitova, Aleksandra M, Márquez-Sánchez, Ana Cristina, Koltsova, Ekaterina K
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.09.2023
Subjects
adipocytes
Adipocytes - pathology
Adipose Tissue - pathology
atherosclerosis
Atherosclerosis - pathology
cytokines
Humans
Immunology
Inflammation
Myeloid Cells - pathology
perivascular adipose tissue
atherosclerosis
perivascular adipose tissue
cytokines
inflammation
adipocytes
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Summary:Adipose tissue inflammation has been implicated in various chronic inflammatory diseases and cancer. Perivascular adipose tissue (PVAT) surrounds the aorta as an extra layer and was suggested to contribute to atherosclerosis development. PVAT regulates the function of endothelial and vascular smooth muscle cells in the aorta and represent a reservoir for various immune cells which may participate in aortic inflammation. Recent studies demonstrate that adipocytes also express various cytokine receptors and, therefore, may directly respond to inflammatory stimuli. Here we will summarize current knowledge on immune mechanisms regulating adipocyte activation and the crosstalk between myeloid cells and adipocytes in pathogenesis of atherosclerosis.
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Edited by: Thomas Riffelmacher, La Jolla Institute for Immunology (LJI), United States
Reviewed by: Nadine Suffee, Sorbonne Universités, France; Felix Sebastian Nettersheim, University Hospital of Cologne, Germany
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1238664