Mammalian artificial chromosomes — vectors for somatic gene therapy

Mammalian artificial chromosomes might prove to be useful vectors for somatic gene therapy. The functional elements of such an artificial chromosome are telomeres, a centromere and a replication origin. Recent progress in the characterization of these functional elements of the eukaryotic chromosome...

Full description

Saved in:
Bibliographic Details
Published inCancer letters Vol. 118; no. 2; pp. 135 - 142
Main Authors Ascenzioni, F., Donini, P., Lipps, H.J.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 14.10.1997
Elsevier
Subjects
Animals
Antineoplastic agents
Biological and medical sciences
Biotechnology
Centromere
Centromeres
Chromosome assembly
Chromosomes
DNA Replication
DNA, Circular
Fundamental and applied biological sciences. Psychology
Gene therapy
General aspects
Genetic Therapy - methods
Genetic Vectors
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Mammals
Medical sciences
Pharmacology. Drug treatments
Replication Origin
Replication origins
Telomerase
Telomere
Telomeres
Chromosome assembly
Telomeres
Replication origins
Centromeres
Vertebrata
Mammalia
Treatment
Centromere
DNA
Production
Replication
Review
Gene therapy
Artificial chromosome
Telomere
Vector
Online AccessGet full text

Cover

More Information
Summary:Mammalian artificial chromosomes might prove to be useful vectors for somatic gene therapy. The functional elements of such an artificial chromosome are telomeres, a centromere and a replication origin. Recent progress in the characterization of these functional elements of the eukaryotic chromosome will be described. Attempts to construct artificial chromosomes for mammalian cells and their use for somatic gene therapy are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(97)00323-6