Diffusion of new drugs in Danish general practice

• Published in: Family practice Vol. 16; no. 4; pp. 407 - 413
• Main Authors: Steffensen, Flemming Hald, Sørensen, Henrik Toft, Olesen, Frede
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.08.1999; Oxford Publishing Limited (England)
• Subjects: Age Distribution; Aged; Attitude of Health Personnel; Denmark; Diffusion of Innovation; Diffusion of innovations; Drug Prescriptions - statistics & numerical data; Drug Therapy - statistics & numerical data; Drug Therapy - trends; Drug Utilization; Drugs; Family Practice - education; Family Practice - statistics & numerical data; Family Practice - trends; Female; General practice; Health Knowledge, Attitudes, Practice; Humans; Logistic Models; Male; Middle Aged; New; Patterns; physician behaviour; Physicians, Family - education; Physicians, Family - psychology; practice characteristics; Practice Patterns, Physicians' - statistics & numerical data; Practice Patterns, Physicians' - trends; Prescribing; prescribing analysis; Sex Distribution; Time Factors
• ISSN: 0263-2136; 1460-2229; 1460-2229
• DOI: 10.1093/fampra/16.4.407

Objectives. There is a large variation in implementing research findings in clinical practice. We examined whether the concept of early or late adopters is universal for the diffusion of all new drugs, and whether it is associated with non-scientific factors in general practice. Methods. We identified all prescriptions for five new drugs from the population-based prescription database in North Jutland County, Denmark (490 000 inhabitants) from 1993 to 1996, and calculated the period from release of the drugs to the issuing of the first prescription by each GP. Logistic regression was performed to predict early or late prescribing from physician characteristics, practice activity and the number of prescriptions, adjusted for age and sex. Results. The distributions of the diffusion time of the drugs by 95 solo practitioners were asymmetrical, with a long upper tail representing the late prescribers. The shape and slope of the diffusion curve were highly drug dependent. There was poor agreement of the three adopter categories (early, intermediate and late prescribers) between the five drugs (kappa < 0.35), but being a late prescriber was the most consistent condition. Late prescribing of tramadol, compared with intermediate prescribing, was associated with female physicians (odds ratio (OR) 5.7; 95% CI 1.5–21.3), smaller list size (OR 0.1; 95% CI 0.0–0.8), a strong general restrictive attitude to pharmacotherapy (OR 0.07; 95% CI 0.01–0.68) and a tendency to lower diagnostic activity per patient (OR 0.4; 95% CI 0.1–1.9). Conclusions. The slope and shape of the diffusion curve are both dependent on physician and drug characteristics, but late prescribers share some common characteristics.