Age-associated decreases in prostaglandin contents in human gastric mucosa

• Published in: Biochemical and biophysical research communications Vol. 186; no. 3; pp. 1443 - 1448
• Main Authors: Goto, Hidemi, Sugiyama, Satoru, Ohara, Atsushi, Hoshino, Hiroshi, Hamajima, Eiji, Kanamori, Shin-ichi, Tsukamoto, Yoshihisa, Ozawa, Takayuki
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 14.08.1992; Elsevier
• Subjects: 6-Ketoprostaglandin F1 alpha - analysis; Adult; age; Aged; Ageing, cell death; Aging - physiology; Biological and medical sciences; Cell physiology; Chromatography, High Pressure Liquid; composition; Dinoprost - analysis; Dinoprostone - analysis; effects on; Fundamental and applied biological sciences. Psychology; gastric mucosa; Gastric Mucosa - growth & development; Gastric Mucosa - metabolism; Humans; man; Middle Aged; Molecular and cellular biology; Prostaglandin D2 - analysis; prostaglandins; Prostaglandins - analysis; stomach; Human; Stomach; Prostaglandin; Correlation analysis; Mucosa; Biosynthesis; Age
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/S0006-291X(05)81568-2

This study was designed to clarify effects of ageing on human gastric mucosal prostaglandin (PG) contents. Forty examinees were divided into 5 age groups of 8 persons each, as follows: age under 40, age 40–49, age 50–59, age 60–69, and age over 70. PG contents in human gastric mucosa were measured by microcolumn high performance liquid chromatography (HPLC) with helium/cadmium laser induced fluorescence detection using biopsy samples obtained by endoscopy. The contents of 6-keto-PGF 1α, PGF 2α, PGE 2, and PGD 2 in the under 40 group were 638±39, 97±16, 468±68, 497±86 (pg/mg tissue), respectively. No significant differences in PG contents among groups aged under 70 were observed. In contrast, significantly low PG contents in the over 70 group were observed, i.e., the contents of 6-keto-PGF 1α, PGF 2α, PGE 2, and PGD 2 were 311±58, 36±8, 196±48, 171±40, respectively, and their contents were significantly lower than those in other age groups. In conclusion, gastric mucosal PG contents decrease significantly in over 70 years-old and this might be a contributing factor in the pathogenesis of gastric ulcers in elderly people.