Age-associated decreases in prostaglandin contents in human gastric mucosa

This study was designed to clarify effects of ageing on human gastric mucosal prostaglandin (PG) contents. Forty examinees were divided into 5 age groups of 8 persons each, as follows: age under 40, age 40–49, age 50–59, age 60–69, and age over 70. PG contents in human gastric mucosa were measured b...

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Published inBiochemical and biophysical research communications Vol. 186; no. 3; pp. 1443 - 1448
Main Authors Goto, Hidemi, Sugiyama, Satoru, Ohara, Atsushi, Hoshino, Hiroshi, Hamajima, Eiji, Kanamori, Shin-ichi, Tsukamoto, Yoshihisa, Ozawa, Takayuki
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 14.08.1992
Elsevier
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Summary:This study was designed to clarify effects of ageing on human gastric mucosal prostaglandin (PG) contents. Forty examinees were divided into 5 age groups of 8 persons each, as follows: age under 40, age 40–49, age 50–59, age 60–69, and age over 70. PG contents in human gastric mucosa were measured by microcolumn high performance liquid chromatography (HPLC) with helium/cadmium laser induced fluorescence detection using biopsy samples obtained by endoscopy. The contents of 6-keto-PGF 1α, PGF 2α, PGE 2, and PGD 2 in the under 40 group were 638±39, 97±16, 468±68, 497±86 (pg/mg tissue), respectively. No significant differences in PG contents among groups aged under 70 were observed. In contrast, significantly low PG contents in the over 70 group were observed, i.e., the contents of 6-keto-PGF 1α, PGF 2α, PGE 2, and PGD 2 were 311±58, 36±8, 196±48, 171±40, respectively, and their contents were significantly lower than those in other age groups. In conclusion, gastric mucosal PG contents decrease significantly in over 70 years-old and this might be a contributing factor in the pathogenesis of gastric ulcers in elderly people.
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ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(05)81568-2