Induction of chromatid aberrations by TEM and maleic hydrazide is differently affected by pretreatment of Vicia faba root-tip meristems with methyl iodide

Treatment of Vicia faba main root meristems with methyl iodide (MeI) 2 h before challenge treatment with triethylene melamine (TEM) significantly reduced the yield of metaphases with chromatid aberrations, i.e., resulted in clastogenic adaptation. Combined treatment with MeI and TEM increased the ab...

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Published inMutation research Vol. 208; no. 2; pp. 101 - 104
Main Authors Rieger, R., Michaelis, A., Schubert, I., Velemínský, J., Gichner, T., Angelis, K.J.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.1988
Subjects
Chromatid aberrations
Chromatids - drug effects
Chromosome Aberrations
Clastogenic adaptation
Drug Interactions
Fabaceae - drug effects
Fabaceae - genetics
Furans - pharmacology
Hydrocarbons, Iodinated - pharmacology
Maleic Anhydrides - pharmacology
Maleic hydrazide
Methyl iodide
Plants, Medicinal
Triethylene melamine
Triethylenemelamine - pharmacology
Vicia faba
Methyl iodide
Chromatid aberrations
Clastogenic adaptation
Vicia faba
Maleic hydrazide
Triethylene melamine
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Summary:Treatment of Vicia faba main root meristems with methyl iodide (MeI) 2 h before challenge treatment with triethylene melamine (TEM) significantly reduced the yield of metaphases with chromatid aberrations, i.e., resulted in clastogenic adaptation. Combined treatment with MeI and TEM increased the aberration yield; MeI treatment alone (10−3 M, 0.5 h) was without clastogenic effect. No protective effects were observed after MeI pretreatment and challenge treatment by maleic hydrazide (MH). The data obtained in V. faba are compared to those previously reported for E. coli.
ISSN:0165-7992
0027-5107
DOI:10.1016/S0165-7992(98)90007-0