Effect of apomorphine on retention of a brightness discrimination in dopamine supersensitive rats

Apomorphine is known to improve the retention performance of a brightness discrimination task after post-training intrahippocampal application to rats. The present study shows that the retention performance of dopamine supersensitive rats was improved by a low dose of apomorphine which was still ine...

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Bibliographic Details
Published inBehavioral and neural biology Vol. 41; no. 1; p. 23
Main Authors Honza, R, Schumacher, H, Klauck, A, Grecksch, G, Matthies, H
Format Journal Article
LanguageEnglish
Published United States 01.01.1984
Subjects
Animals
Apomorphine - pharmacology
Discrimination Learning - drug effects
Dose-Response Relationship, Drug
Haloperidol - pharmacology
Hippocampus - drug effects
Humans
Male
Memory - drug effects
Rats
Receptors, Dopamine - pharmacology
Retention (Psychology) - drug effects
Stereotyped Behavior - drug effects
Visual Perception - drug effects
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Summary:Apomorphine is known to improve the retention performance of a brightness discrimination task after post-training intrahippocampal application to rats. The present study shows that the retention performance of dopamine supersensitive rats was improved by a low dose of apomorphine which was still ineffective in control animals. Dopamine supersensitivity by itself had no effect on acquisition and retention parameters of brightness discrimination. The result further supports the assumption that dopamine receptors in rat hippocampus can modulate the formation of memory.
ISSN:0163-1047
DOI:10.1016/S0163-1047(84)90680-0