Quinolinic Acid: An Endogenous Metabolite that Produces Axon-Sparing Lesions in Rat Brain

A current hypothesis links the neuroexcitatory properties of certain acidic amino acids to their ability to cause selective neuronal lesions. Intracerebral injection of the neuroexcitatory tryptophan metabolite, quinolinic acid, has behavioral, neurochemical, and neuropathological consequences remin...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 219; no. 4582; pp. 316 - 318
Main Authors Schwarcz, Robert, Whetsell, William O., Mangano, Richard M.
Format Journal Article
LanguageEnglish
Published United States The American Association for the Advancement of Science 21.01.1983
Subjects
Acidic amino acids
Amino acids
Animals
Axons - drug effects
Brain
Brain - drug effects
Brain - enzymology
Corpus Striatum - drug effects
Corpus Striatum - enzymology
Corpus Striatum - ultrastructure
Dosage
Excitatory amino acids
Hippocampus - drug effects
Lesions
Neuroglia
Neuroglia - drug effects
Neurons
Neurons - drug effects
Pyramidal cells
Pyridines - pharmacology
Quinolinic Acids - pharmacology
Rats
Toxins
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Summary:A current hypothesis links the neuroexcitatory properties of certain acidic amino acids to their ability to cause selective neuronal lesions. Intracerebral injection of the neuroexcitatory tryptophan metabolite, quinolinic acid, has behavioral, neurochemical, and neuropathological consequences reminiscent of those of exogenous excitotoxins, such as kainic and ibotenic acids. Its qualities as a neurotoxic agent suggest that quinolinic acid should be considered as a possible pathogenic factor in neurodegenerative disorders.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6849138