Pathogenesis and Management of Polyomavirus Infection in Transplant Recipients
Polyomaviruses (JC virus [JCV], BK virus [BKV], and simian virus 40 [SV40]) establish subclinical and persistent infections and share the capacity for reactivation from latency in their host under immunosuppression. JCV establishes latency mainly in the kidney, and its reactivation results in the de...
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Published in | Clinical infectious diseases Vol. 35; no. 9; pp. 1081 - 1087 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
The University of Chicago Press
01.11.2002
University of Chicago Press |
Subjects | |
Online Access | Get full text |
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Summary: | Polyomaviruses (JC virus [JCV], BK virus [BKV], and simian virus 40 [SV40]) establish subclinical and persistent infections and share the capacity for reactivation from latency in their host under immunosuppression. JCV establishes latency mainly in the kidney, and its reactivation results in the development of progressive multifocal leukoencephalopathy. BKV causes infection in the kidney and the urinary tract, and its activation causes a number of disorders, including nephropathy and hemorrhagic cystitis. Recent studies have reported SV40 in the allografts of children who received renal transplants and in the urine, blood, and kidneys of adults with focal segmental glomerulosclerosis, which is a cause of end-stage renal disease and an indication for kidney transplantation. Clinical syndromes related to polyomavirus infection are summarized in the present review, and strategies for the management of patients who receive transplants are discussed. |
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Bibliography: | ark:/67375/HXZ-0KZ3X5D7-P istex:B64D3FC82B031F5ED422300C08BDA2F9E23CC211 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1058-4838 1537-6591 |
DOI: | 10.1086/344060 |