Direct Asymmetric Arylation of Imines

The Friedel‐Crafts reaction represents one of the most efficient tools for the formation of carbon‐carbon bonds and direct derivatization of aromatic compounds. Asymmetric arylation of imines involving Friedel‐Crafts reaction has received much interest recently. The present review summarizes the wor...

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Published inAdvanced synthesis & catalysis Vol. 362; no. 20; pp. 4293 - 4324
Main Authors Egorov, Ilya N., Santra, Sougata, Kopchuk, Dmitry S., Kovalev, Igor S., Zyryanov, Grigory V., Majee, Adinath, Ranu, Brindaban C., Rusinov, Vladimir L., Chupakhin, Oleg N.
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 21.10.2020
Subjects
Aromatic compounds
Aryl boronic acids
Arylation
Asymmetric synthesis
Asymmetry
Aza-Friedel Crafts reaction
Carbon
Chemical bonds
Chiral catalyst
Friedel-Crafts reaction
Imines
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Summary:The Friedel‐Crafts reaction represents one of the most efficient tools for the formation of carbon‐carbon bonds and direct derivatization of aromatic compounds. Asymmetric arylation of imines involving Friedel‐Crafts reaction has received much interest recently. The present review summarizes the works on the asymmetric arylation of imines by different approaches including Friedel‐Crafts reaction and their development to date. The review is divided into three main sections: addition reaction of arenes to imines in the presence of chiral catalysts; addition reaction of arenes to imines containing chiral tails and asymmetric coupling reaction of aryl boronic acids and imines.
Bibliography:Dedicated to Prof. Vasily A. Bakulev on the occasion of his 70th birthday
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000548