From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited

• Published in: Phytotherapy research Vol. 15; no. 1; pp. 76 - 78
• Main Authors: Rihn, Bertrand, Saliou, Claude, Bottin, Marie Claire, Keith, Gerard, Packer, Lester
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.02.2001; Wiley
• Subjects: Biological and medical sciences; Cell Line - drug effects; dermatoses; Flavonoids - pharmacology; Flavonoids - therapeutic use; Gene Expression Regulation; General pharmacology; high density filter array; Humans; Keratinocytes - drug effects; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; pine bark extract; Plants, Medicinal; psoriasis; Skin Diseases - drug therapy; Skin Diseases - genetics; Human; Skin disease; Cell line; Psoriasis; Pharmacognosy; Bark; Plant origin; Keratinocyte; Gene expression; In vitro; Biological activity; Medicinal plant
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/1099-1573(200102)15:1<76::AID-PTR747>3.0.CO;2-O

The effect of French maritime pine bark extract (PBE) on the gene expression profile of HaCaT human keratinocytes was studied using high density filter arrays. The expression profile of both control and PBE‐treated cells was determined. Interestingly, PBE was shown to downregulate both calgranulin A and B genes which are known to be upregulated in psoriasis and various dermatoses. Thus, PBE could be considered in human dermatoses. Copyright © 2001 John Wiley & Sons, Ltd.