The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy-induced and radiotherapy-induced toxicity

• Published in: Cell biochemistry and function Vol. 30; no. 5; pp. 438 - 443
• Main Authors: Akyol, Sumeyya, Ginis, Zeynep, Armutcu, Ferah, Ozturk, Gulfer, Yigitoglu, M. Ramazan, Akyol, Omer
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.07.2012; Wiley Subscription Services, Inc
• Subjects: Animals; antineoplastic; Antineoplastic Combined Chemotherapy Protocols - antagonists & inhibitors; Antineoplastic Combined Chemotherapy Protocols - toxicity; Antioxidants; Apis mellifera; caffeic acid phenethyl ester (CAPE); Caffeic Acids - chemistry; Caffeic Acids - pharmacology; cancer; Neoplasms, Experimental - drug therapy; Neoplasms, Experimental - pathology; Neoplasms, Experimental - radiotherapy; Neoplasms, Experimental - therapy; Phenylethyl Alcohol - analogs & derivatives; Phenylethyl Alcohol - chemistry; Phenylethyl Alcohol - pharmacology; side effect; treatment
• ISSN: 0263-6484; 1099-0844
• DOI: 10.1002/cbf.2817

Protection of the patients against the side effects of chemotherapy and radiotherapy regimens has attracted increasing interest of clinicians and practitioners. Caffeic acid phenethyl ester (CAPE), which is extracted from the propolis of honeybee hives as an active component, specifically inhibits nuclear factor κB at micromolar concentrations and show ability to stop 5‐lipoxygenase‐catalysed oxygenation of linoleic acid and arachidonic acid. CAPE has antiinflammatory, antiproliferative, antioxidant, cytostatic, antiviral, antibacterial, antifungal and antineoplastic properties. The purpose of this review is to summarize in vivo and in vitro usage of CAPE to prevent the chemotherapy‐induced and radiotherapy‐induced damages and side effects in experimental animals and to develop a new approach for the potential usage of CAPE in clinical trial as a protective agent during chemotherapy and radiotherapy regimens. Copyright © 2012 John Wiley & Sons, Ltd.