Association of functional polymorphisms in FAS and FAS Ligand genes promoter with pre-eclampsia

Aim Pre‐eclampsia (PE) is a complex disorder of pregnancy with unknown etiology. FAS‐mediated apoptosis is assumed to prevent the development of PE; therefore FAS and FAS Ligand may be represented as candidate genes involved in PE pathogenesis. In the present study, we evaluated the relation between...

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Published inThe journal of obstetrics and gynaecology research Vol. 40; no. 5; pp. 1167 - 1173
Main Authors Salimi, Saeedeh, Moudi, Bita, Farajian Mashhadi, Farzaneh, Tavilani, Heidar, Hashemi, Mohammad, Zand, Hamid, Yaghmaei, Minoo
Format Journal Article
LanguageEnglish
Published Australia Blackwell Publishing Ltd 01.05.2014
Subjects
Adult
FAS
FAS Ligand
Fas Ligand Protein - genetics
fas Receptor - genetics
Female
Genotype
Humans
Male
polymorphism
Polymorphism, Single Nucleotide
pre-eclampsia
Pre-Eclampsia - genetics
Pregnancy
Promoter Regions, Genetic
FAS
polymorphism
pre-eclampsia
FAS Ligand
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Summary:Aim Pre‐eclampsia (PE) is a complex disorder of pregnancy with unknown etiology. FAS‐mediated apoptosis is assumed to prevent the development of PE; therefore FAS and FAS Ligand may be represented as candidate genes involved in PE pathogenesis. In the present study, we evaluated the relation between FAS Ligand A‐670G (rs1800682) and FAS Ligand C‐844T (rs763110) gene polymorphisms with PE in southeast Iran. Methods One hundred and twenty‐seven unrelated women with PE and 139 healthy control subjects were genotyped for the FAS A‐670G and FAS Ligand C‐844T polymorphisms by polymerase chain reaction restriction fragment length polymorphism method. Results The AA, AG and GG genotype frequency of the FAS A‐670G polymorphism were 21.3%, 53.5% and 25.2% in pre‐eclamptic women and 46.0%, 41.5% and 11.5% in controls and were statistically different (P = 0.0001). The risk of PE was 2.7‐ and 4.7‐fold higher in pregnant women with AG and GG genotypes respectively. Although the frequency TT genotype and T allele of FAS Ligand C‐844T gene polymorphism was higher in the PE group, the differences were not significant. Conclusion FAS A‐670G polymorphism is associated with a higher risk for PE. There was no association between FAS Ligand C‐844T polymorphism and PE.
Bibliography:Zahedan University of Medical Sciences
ArticleID:JOG12327
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ark:/67375/WNG-WVHSRRDF-1
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1341-8076
1447-0756
1447-0756
DOI:10.1111/jog.12327