FOXP3 genetic variant and risk of acute coronary syndrome in Chinese Han population

• Published in: Cell biochemistry and function Vol. 31; no. 7; pp. 599 - 602
• Main Authors: Yang, Qing, Chen, Yu, Yong, Wei
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.10.2013; Wiley Subscription Services, Inc
• Subjects: acute coronary syndrome; Acute Coronary Syndrome - ethnology; Acute Coronary Syndrome - genetics; Aged; Asian Continental Ancestry Group; Cardiovascular diseases; Coronary heart disease; Female; Forkhead Transcription Factors - genetics; FOXP3; Genetic Association Studies; genetic polymorphisms; Genetic Predisposition to Disease; Genetic variance; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; genetic polymorphisms; FOXP3; acute coronary syndrome
• ISSN: 0263-6484; 1099-0844; 1099-0844
• DOI: 10.1002/cbf.2945

Coronary artery disease is the most common type of heart disease and a leading cause of morbidity and mortality all over the world. Acute coronary syndrome (ACS) is the most serious form of coronary artery disease. Recently, many studies indicated that genetic susceptibility may play a vital role in the pathogenesis of coronary heart disease including ACS. Forkhead/winged helix transcription factor (FOXP3) gene polymorphisms have been previously found to be associated with inflammatory diseases. To determine whether FOXP3 polymorphisms are associated with ACS, we examined the single nucleotide polymorphism rs3761548 of FOXP3 gene by polymerase chain reaction—polyacrylamide gel electrophoresis in 226 ACS patients and 259 unrelated healthy subjects. Our results showed that single nucleotide polymorphism rs3761548 had association with ACS in Chinese Han population. These data indicate that, for the first time, FOXP3 gene polymorphism may appear to play an important role in the susceptibility of ACS in Chinese Han population. Copyright © 2013 John Wiley & Sons, Ltd.