Cytotoxic effects of plant extracts from the families Fabaceae, Oleaceae, Philadelphaceae, Rosaceae and Staphyleaceae

• Published in: Phytotherapy research Vol. 15; no. 1; pp. 22 - 25
• Main Authors: Jantova, S., Nagy, M., Ruz̆eková, L'., Granc̆ai, D.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.02.2001; Wiley
• Subjects: Biological and medical sciences; Cell Division - drug effects; cytotoxicity; General pharmacology; HeLa Cells - drug effects; Humans; inhibition of growth tumour cell line; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; plant extracts; Plant Extracts - pharmacology; Plants, Medicinal; Antineoplastic agent; Human; Oleaceae; Pharmacognosy; Rosaceae; Cytotoxicity; In vitro; Biological activity; Medicinal plant; Staphyleaceae; Leguminosae; Dicotyledones; Angiospermae; Established cell line; Plant origin; Spermatophyta
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/1099-1573(200102)15:1<22::AID-PTR774>3.0.CO;2-A

A human transformed line of HeLa cells was treated with extracts prepared from Gymnocladus dioicus, Holodiscus discolor, Stephanandra tanakae, Ligustrum delavayanum, Ligustrum vulgare and Staphylea pinnata. The study evaluating the influence of the active extracts on HeLa cell division also reveals their acute, delayed and combined effect. A 35% degradation of HeLa cells was found after 72 h treatment with 62.5 µg/mL of the extract isolated from Stephanandra tanakae. A 100% lysis of HeLa cells was observed after 72 h treatment with a 125 µg/mL concentration of the extract prepared from Gymnocladus dioicus. The extracts from Ligustrum devayanum and Ligustrum vulgare were specifically effective only with HeLa cells. On the other hand, the extract prepared from Gymnocladus dioicus was effective on the bacteria and on the HeLa cells. Copyright © 2001 John Wiley & Sons, Ltd.