Significance of serum immunoglobulin G for leukocytosis and prognosis in childhood B-lineage acute lymphoblastic leukemia

• Published in: Pediatric Blood & Cancer Vol. 42; no. 5; pp. 421 - 426
• Main Authors: Potapnev, Michael P., Belevtsev, Michael V., Bortkevich, Ludmila G., Grinev, Vasily V., Martsev, Sergey P., Kravchuk, Zinaida I., Migal, Natalia V., Aleinikova, Olga V.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2004; Wiley
• Subjects: Adolescent; Antibodies, Neoplasm - blood; Biological and medical sciences; Burkitt Lymphoma - diagnosis; Burkitt Lymphoma - immunology; Burkitt Lymphoma - pathology; Case-Control Studies; Child; Child, Preschool; childhood B-lineage ALL; Female; Hematologic and hematopoietic diseases; Humans; Immunoglobulin G - blood; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Leukocytosis - immunology; Male; Medical sciences; overall survival; peripheral leukemic cell count; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology; Prognosis; serum Igs; Survival Analysis; Treatment Outcome; Human; Prognosis; Acute; IgG; Malignant hemopathy; B-Lymphocyte; Survival; peripheral leukemic cell count; Leukocytosis; Lymphoproliferative syndrome; overall survival; Serum; Acute lymphocytic leukemia; childhood B-lineage ALL; serum Igs; Cell; Child
• ISSN: 1545-5009; 1545-5017; 1096-911X
• DOI: 10.1002/pbc.20014

Background This study was conducted to evaluate the significance of serum level of immunoglobulins (Igs) and particularly IgG for leukemic cell persistence in peripheral blood (PB) and prognosis for childhood acute lymphoblastic leukemia (ALL). Procedure Human sera were obtained from 68 children with primary B‐lineage ALL at diagnosis and 46 healthy children (control). Serum level of IgM, IgG, IgA, IgG1, IgG2, IgG3, IgG4, antitumor antibody, homogeneous IgG were quantified by turbidimetric or enzyme‐linked immunosorbent assays. Results The mean values of serum IgM, IgG, IgA at diagnosis were not differed significantly in ALL patients and control children. The level of IgM and IgG1 inversely correlated with white blood cell (WBC) count in PB of patients. Normal range of serum IgG, separated by 25th and 75th percentiles of IgG variables, was associated in patients with decreased WBC count in PB but not in bone marrow (BM) versus patients with low concentration of IgG. Normal range of IgG also favors low frequency of homogeneous IgG and antitumor antibodies. Patients with high level of IgG, besides increased frequency of homogeneous IgG and antitumor antibodies, had worse 3‐year overall survival (OS) rate as compared to patients with normal level of IgG (58.8 vs. 91.2%, P = 0.014). Conclusions The normal level of serum IgG at diagnosis is a beneficial prognostic factor associated with lower rate of leukemic cell persistence in PB and better outcome of childhood B‐lineage ALL. © 2004 Wiley‐Liss, Inc.