The effects of preemptive pregabalin on attenuation of stress response to endotracheal intubation and opioid- sparing effect in patients undergoing off-pump coronary artery bypass grafting

• Published in: Annals of cardiac anaesthesia Vol. 15; no. 1; pp. 18 - 25
• Main Authors: Sundar, Ayya, Kodali, Rajeshkumar, Sulaiman, Sajith, Ravullapalli, Harish, Karthekeyan, Ranjith, Vakamudi, Mahesh
• Format: Journal Article
• Language: English
• Published: Mumbai Medknow Publications and Media Pvt. Ltd 01.01.2012; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Anesthesia; biomarker; Blood pressure; Cardiac surgery; Coronary artery bypass; Diabetic neuropathy; Dosage and administration; Drug dosages; Drug therapy; Hypertension; intensive care unit; Intubation; intubation response; off-pump; Off-pump coronary artery bypass grafting; Postoperative period; predictor; Pregabalin; Preoperative care; seizures; Stress response; Studies; Surgery; Trachea; tranexamic acid; urinary neutrophil gelatinase-associated lipocalin; Veins & arteries; India
• ISSN: 0971-9784; 0974-5181
• DOI: 10.4103/0971-9784.91473

The clinical study was designed to evaluate and compare single preoperative dose of pregabalin to a placebo regarding hemodynamic responses to laryngoscopy and endotracheal intubation, to assess perioperative fentanyl requirement and any side-effects. It was a randomized, double-blind, placebo-controlled, parallel assignment, efficacy study. The study was done at a tertiary university hospital. This study was a comparison between two groups of 30 adult patients scheduled for elective off pump coronary artery bypass surgery. In the control group, the patients were given placebo capsules, and in the pregabalin group, the patients were given pregabalin 150 mg capsule orally 1 h before surgery. The patients were compared for hemodynamic changes before the start of the surgery, after induction, 1, 3, and 5 min after intubation. Additionally, fentanyl requirement during surgery and the first postoperative day was also compared. The present study shows that a single oral dose of 150 mg pregabalin given 1 h before surgery attenuated the pressor response to tracheal intubation in adults, but the drug did not show any effect on perioperative opioid consumption and was devoid of side-effects in the given dose.