FLUVIRUCINS A1, A2, B1, B2, B3, B4 AND B5, NEW ANTIBIOTICS ACTIVE AGAINST INFLUENZA A VIRUS I. PRODUCTION, ISOLATION, CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

• Published in: Journal of antibiotics Vol. 44; no. 7; pp. 733 - 740
• Main Authors: NARUSE, NOBUAKI, TENMYO, OSAMU, KAWANO, KIMIO, TOMITA, KOJI, OHGUSA, NORIYUKI, MIYAKI, TAKEO, KONISHI, MASATAKA, OKI, TOSHIKAZU
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1991; Japan Antibiotics Research Association
• Subjects: Actinomycetales - classification; Actinomycetales - metabolism; Animals; Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antiviral Agents - chemistry; Antiviral Agents - isolation & purification; Antiviral Agents - pharmacology; Applied microbiology; Biological and medical sciences; Cell Line; Chemical Phenomena; Chemistry, Physical; Chemotherapic agents; Deoxy Sugars - chemistry; Deoxy Sugars - isolation & purification; Deoxy Sugars - pharmacology; Dogs; Fermentation; Fundamental and applied biological sciences. Psychology; Influenza A virus - drug effects; Lactams - chemistry; Lactams - isolation & purification; Lactams - pharmacology; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microbiology; Spectrophotometry, Infrared; Fissipedia; Cell culture; Carnivora; Molecular structure; Orthomyxoviridae; Influenzavirus; In vitro; Kidney; Virus; Vertebrata; Mammalia; Influenzavirus A; Sensitivity resistance; Urinary system; Microbial origin; Animal; Production; Bacteria; Antiviral; Isolation; Actinomycetes; Infected cell; Dog; Physicochemical properties
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.44.733

Five unidentified actinomycete strains produced a series of novel antiviral antibiotics which have a unique 2, 6-dialkyl-10-ethyl-3(or 9)-hydroxy-13-tridecanelactam nucleus substituted with 3-amino-3, 6-dideoxy-L-talose or 3-amino-3, 6-dideoxy-L-mannose(L-mycosamine). The antibiotic components exhibited potent inhibitory activity against influenza virus type A Victoria strain infection in Madin Darby canine kidney cells by the cytopathic effect reduction assay.