Recent Advances in Squaramide‐Catalyzed Asymmetric Mannich Reactions

Bifunctional squaramides as a branch of organo‐catalysts showed powerful strategies in the art of asymmetric synthesis, and they have been proved to be highly efficient and versatile catalysts for constructing complex molecular structures and chiral biologically active compounds. In this review, we...

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Published inAdvanced synthesis & catalysis Vol. 362; no. 21; pp. 4487 - 4512
Main Authors Hou, Xi‐Qiang, Du, Da‐Ming
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 04.11.2020
Subjects
Asymmetric synthesis
Asymmetry
Catalysts
Chemical reactions
Hydrogen bonds
Mannich reactions
Molecular structure
Organocatalysis
Squaramides
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Summary:Bifunctional squaramides as a branch of organo‐catalysts showed powerful strategies in the art of asymmetric synthesis, and they have been proved to be highly efficient and versatile catalysts for constructing complex molecular structures and chiral biologically active compounds. In this review, we summarized recent advances in bifunctional squaramide‐catalyzed asymmetric Mannich reactions.
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ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000842