A child with BK virus infection: Inadequacy of current therapeutic strategies

Pereira T, Rojas CP, Garcia‐Buitrago MT, Chandar J, Abitbol C, Seeherunvong W, Rusconi P, Bruce JH, Zilleruelò G. A child with BK virus infection: Inadequacy of current therapeutic strategies. 
Pediatr Transplantation 2011. © 2011 John Wiley & Sons A/S. :  In this report, we describe the develop...

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Published inPediatric transplantation Vol. 16; no. 7; pp. E269 - E274
Main Authors Pereira, Tanya, Rojas, Claudia P., Garcia‐Buitrago, Monica T., Chandar, Jayanthi, Abitbol, Carolyn, Seeherunvong, Wacharee, Rusconi, Paolo, Bruce, Jocelyn H., Zilleruelò, Gaston
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.11.2012
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Summary:Pereira T, Rojas CP, Garcia‐Buitrago MT, Chandar J, Abitbol C, Seeherunvong W, Rusconi P, Bruce JH, Zilleruelò G. A child with BK virus infection: Inadequacy of current therapeutic strategies. 
Pediatr Transplantation 2011. © 2011 John Wiley & Sons A/S. :  In this report, we describe the development of BKVN in the native kidneys of a child with a cardiac transplant. Elevated BK viral DNA load by PCR necessitated a prolonged course of treatment with escalating doses of cidofovir. Despite a reduction in plasma BK viral load, the infection evolved into an invasive CNS disease, resulting in rhomboencephalitis. This case highlights the need for awareness of the possibility of developing multiorgan complications from BKV infection. The current treatment options for BKV tissue invasive disease are inadequate and need to be improved.
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ISSN:1397-3142
1399-3046
DOI:10.1111/j.1399-3046.2011.01602.x