Changes in PEDF, MMP-2, and TGF-β2 levels in the aqueous humor of cataract patients and their correlation with disease severity
•PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in cataracts.•The combined detection was valuable in evaluating cataract development.•MMP-2, TGF-β2, and PEDF were risk factors for cataract development. To explore the changes of Pigment Epithelium-Derived Factor (PEDF), Matrix Metallo...
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| Published in | Clinics (São Paulo, Brazil) Vol. 79; p. 100402 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier España, S.L.U
01.01.2024
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Faculdade de Medicina / USP |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1807-5932 1980-5322 1980-5322 |
| DOI | 10.1016/j.clinsp.2024.100402 |
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| Abstract | •PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in cataracts.•The combined detection was valuable in evaluating cataract development.•MMP-2, TGF-β2, and PEDF were risk factors for cataract development.
To explore the changes of Pigment Epithelium-Derived Factor (PEDF), Matrix Metalloproteinase-2 (MMP-2), and Transforming Growth Factor-β2 (TGF-β2) levels in the aqueous humor of cataract patients and their correlation with disease severity.
93 cataract patients and 56 healthy subjects were study objects. PEDF, MMP-2, and TGF-β2 levels of aqueous humor were compared, and the correlation between each index and Lens Opacity Classification System (LOCS) III classification was analyzed. ROC curve was used to analyze the evaluation value of the combined detection of each index on cataract development, and logistic regression to analyze the influence of the changes of each index on cataract development.
PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in the aqueous humor of cataract patients than in healthy subjects. PEDF levels in the aqueous humor were negatively correlated with LOCS III classification, while MMP-2 and TGF-β2 levels were positively correlated with LOCS III classification. The AUC value of combined detection was higher than that of PEDF, MMP-2, and TGF-β2 in the aqueous humor alone. MMP-2 ≥ 15.13 pg/mL, TGF-β2 ≥ 385.91 pg/mL and PEDF < 198.85 ng/mL were risk factors for cataract development.
The changes in PEDF, MMP-2, and TGF-β2 levels in the aqueous humor of cataract patients are related to LOCS III classification. The combined detection is valuable in evaluating cataract development. |
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| AbstractList | To explore the changes of Pigment Epithelium-Derived Factor (PEDF), Matrix Metalloproteinase-2 (MMP-2), and Transforming Growth Factor-β2 (TGF-β2) levels in the aqueous humor of cataract patients and their correlation with disease severity.OBJECTIVETo explore the changes of Pigment Epithelium-Derived Factor (PEDF), Matrix Metalloproteinase-2 (MMP-2), and Transforming Growth Factor-β2 (TGF-β2) levels in the aqueous humor of cataract patients and their correlation with disease severity.93 cataract patients and 56 healthy subjects were study objects. PEDF, MMP-2, and TGF-β2 levels of aqueous humor were compared, and the correlation between each index and Lens Opacity Classification System (LOCS) III classification was analyzed. ROC curve was used to analyze the evaluation value of the combined detection of each index on cataract development, and logistic regression to analyze the influence of the changes of each index on cataract development.METHODS93 cataract patients and 56 healthy subjects were study objects. PEDF, MMP-2, and TGF-β2 levels of aqueous humor were compared, and the correlation between each index and Lens Opacity Classification System (LOCS) III classification was analyzed. ROC curve was used to analyze the evaluation value of the combined detection of each index on cataract development, and logistic regression to analyze the influence of the changes of each index on cataract development.PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in the aqueous humor of cataract patients than in healthy subjects. PEDF levels in the aqueous humor were negatively correlated with LOCS III classification, while MMP-2 and TGF-β2 levels were positively correlated with LOCS III classification. The AUC value of combined detection was higher than that of PEDF, MMP-2, and TGF-β2 in the aqueous humor alone. MMP-2 ≥ 15.13 pg/mL, TGF-β2 ≥ 385.91 pg/mL and PEDF < 198.85 ng/mL were risk factors for cataract development.RESULTSPEDF levels were lower and MMP-2 and TGF-β2 levels were higher in the aqueous humor of cataract patients than in healthy subjects. PEDF levels in the aqueous humor were negatively correlated with LOCS III classification, while MMP-2 and TGF-β2 levels were positively correlated with LOCS III classification. The AUC value of combined detection was higher than that of PEDF, MMP-2, and TGF-β2 in the aqueous humor alone. MMP-2 ≥ 15.13 pg/mL, TGF-β2 ≥ 385.91 pg/mL and PEDF < 198.85 ng/mL were risk factors for cataract development.The changes in PEDF, MMP-2, and TGF-β2 levels in the aqueous humor of cataract patients are related to LOCS III classification. The combined detection is valuable in evaluating cataract development.CONCLUSIONThe changes in PEDF, MMP-2, and TGF-β2 levels in the aqueous humor of cataract patients are related to LOCS III classification. The combined detection is valuable in evaluating cataract development. • PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in cataracts. • The combined detection was valuable in evaluating cataract development. • MMP-2, TGF-β2, and PEDF were risk factors for cataract development. •PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in cataracts.•The combined detection was valuable in evaluating cataract development.•MMP-2, TGF-β2, and PEDF were risk factors for cataract development. To explore the changes of Pigment Epithelium-Derived Factor (PEDF), Matrix Metalloproteinase-2 (MMP-2), and Transforming Growth Factor-β2 (TGF-β2) levels in the aqueous humor of cataract patients and their correlation with disease severity. 93 cataract patients and 56 healthy subjects were study objects. PEDF, MMP-2, and TGF-β2 levels of aqueous humor were compared, and the correlation between each index and Lens Opacity Classification System (LOCS) III classification was analyzed. ROC curve was used to analyze the evaluation value of the combined detection of each index on cataract development, and logistic regression to analyze the influence of the changes of each index on cataract development. PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in the aqueous humor of cataract patients than in healthy subjects. PEDF levels in the aqueous humor were negatively correlated with LOCS III classification, while MMP-2 and TGF-β2 levels were positively correlated with LOCS III classification. The AUC value of combined detection was higher than that of PEDF, MMP-2, and TGF-β2 in the aqueous humor alone. MMP-2 ≥ 15.13 pg/mL, TGF-β2 ≥ 385.91 pg/mL and PEDF < 198.85 ng/mL were risk factors for cataract development. The changes in PEDF, MMP-2, and TGF-β2 levels in the aqueous humor of cataract patients are related to LOCS III classification. The combined detection is valuable in evaluating cataract development. To explore the changes of Pigment Epithelium-Derived Factor (PEDF), Matrix Metalloproteinase-2 (MMP-2), and Transforming Growth Factor-β2 (TGF-β2) levels in the aqueous humor of cataract patients and their correlation with disease severity. 93 cataract patients and 56 healthy subjects were study objects. PEDF, MMP-2, and TGF-β2 levels of aqueous humor were compared, and the correlation between each index and Lens Opacity Classification System (LOCS) III classification was analyzed. ROC curve was used to analyze the evaluation value of the combined detection of each index on cataract development, and logistic regression to analyze the influence of the changes of each index on cataract development. PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in the aqueous humor of cataract patients than in healthy subjects. PEDF levels in the aqueous humor were negatively correlated with LOCS III classification, while MMP-2 and TGF-β2 levels were positively correlated with LOCS III classification. The AUC value of combined detection was higher than that of PEDF, MMP-2, and TGF-β2 in the aqueous humor alone. MMP-2 ≥ 15.13 pg/mL, TGF-β2 ≥ 385.91 pg/mL and PEDF < 198.85 ng/mL were risk factors for cataract development. The changes in PEDF, MMP-2, and TGF-β2 levels in the aqueous humor of cataract patients are related to LOCS III classification. The combined detection is valuable in evaluating cataract development. ABSTRACT Objective: To explore the changes of Pigment Epithelium-Derived Factor (PEDF), Matrix Metalloproteinase-2 (MMP-2), and Transforming Growth Factor-β2 (TGF-β2) levels in the aqueous humor of cataract patients and their correlation with disease severity. Methods: 93 cataract patients and 56 healthy subjects were study objects. PEDF, MMP-2, and TGF-β2 levels of aqueous humor were compared, and the correlation between each index and Lens Opacity Classification System (LOCS) III classification was analyzed. ROC curve was used to analyze the evaluation value of the combined detection of each index on cataract development, and logistic regression to analyze the influence of the changes of each index on cataract development. Results: PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in the aqueous humor of cataract patients than in healthy subjects. PEDF levels in the aqueous humor were negatively correlated with LOCS III classification, while MMP-2 and TGF-β2 levels were positively correlated with LOCS III classification. The AUC value of combined detection was higher than that of PEDF, MMP-2, and TGF-β2 in the aqueous humor alone. MMP-2 ≥ 15.13 pg/mL, TGF-β ≥ 385.91 pg/mL and PEDF < 198.85 ng/mL were risk factors for cataract development. Conclusion: The changes in PEDF, MMP-2, and TGF-β2 levels in the aqueous humor of cataract patients are related to LOCS III classification. The combined detection is valuable in evaluating cataract development. |
| ArticleNumber | 100402 |
| Author | Chen, Xiao Luan Lin, Yong Feng Xie, Jin Xia |
| AuthorAffiliation | Longyan People’s Hospital Longyan Hospital of Traditional Chinese Medicine affiliated to Xiamen University |
| AuthorAffiliation_xml | – name: Longyan Hospital of Traditional Chinese Medicine affiliated to Xiamen University – name: Longyan People’s Hospital |
| Author_xml | – sequence: 1 givenname: Yong Feng orcidid: 0009-0009-7425-8956 surname: Lin fullname: Lin, Yong Feng email: lllin_yongfeng1367@outlook.com organization: Department of Ophthalmology, Longyan People's Hospital, Longyan City, Fujian Province, China – sequence: 2 givenname: Jin Xia orcidid: 0009-0006-7152-0005 surname: Xie fullname: Xie, Jin Xia organization: Department of Ophthalmology, Longyan People's Hospital, Longyan City, Fujian Province, China – sequence: 3 givenname: Xiao Luan orcidid: 0009-0000-4328-9922 surname: Chen fullname: Chen, Xiao Luan organization: Department of General Surgery, Longyan Hospital of Traditional Chinese Medicine affiliated to Xiamen University, Longyan City, Fujian Province, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39413500$$D View this record in MEDLINE/PubMed |
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| Keywords | Aqueous Humor LOCS III Classification Cataract Pigment Epithelial-Derived Factor Matrix Metalloproteinase-2 Transforming Growth Factor-β2 |
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Mol Histol – volume: 68 start-page: 10 issue: 8 year: 2017 end-page: 19 article-title: Matrix metalloproteinase and their inhibitors concentration and activity variations in aqueous humor and plasma of glaucoma patients. publication-title: Revista Chimie – volume: 28 start-page: 247 issue: 4 year: 2008 end-page: 260 article-title: The surgical management of cataract: barriers, best practices and outcomes. publication-title: Int Ophthalmol – volume: 47 start-page: 206 issue: 2 year: 2022 end-page: 213 article-title: Effect of thyroxine on transforming growthfactor beta 1, collagen I, and Vexpression in keratoconus corneal fibroblasts and keratocytes, in vitro. publication-title: Curr Eye Res – volume: 35 issue: 6 year: 2021 article-title: Pigment epithelium-derived factor negates oxidative stress in mouse oocytes. publication-title: FASEB J – volume: 21 start-page: 100576 issue: 4 year: 2021 end-page: 100576 article-title: Upregulated pigment epithelium-derived factor (PEDF) promotes trophoblast apoptosis and inhibits invasion in preeclampsia. publication-title: Reprod Biol – volume: 42 start-page: 3591 issue: 6 year: 2018 end-page: 3601 article-title: The role of focal adhesion kinase in transforming growth factor-β2 induced migration of human lens epithelial cells. publication-title: Int J Mol Med – volume: 49 start-page: 524 issue: 5 year: 2020 end-page: 534 article-title: The miR-29b/Matrix metalloproteinase 2 axis regulates transdifferentiation and calcification of vascular smooth muscle cells in a calcified environment. publication-title: Blood Purif – volume: 47 start-page: 735 issue: 5 year: 2022 end-page: 746 article-title: Interfering Hsa_circRNA_0060640 Suppresses TGF-beta 2-Induced Proliferation, Motility and EMT in human lens epithelium cells by targeting miR-214-3p and Collagen Type I alpha2 Chain. publication-title: Curr Eye Res – volume: 12 start-page: 1317 year: 2018 end-page: 1324 article-title: Clinical outcomes following trifocal diffractive 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| Snippet | •PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in cataracts.•The combined detection was valuable in evaluating cataract development.•MMP-2,... To explore the changes of Pigment Epithelium-Derived Factor (PEDF), Matrix Metalloproteinase-2 (MMP-2), and Transforming Growth Factor-β2 (TGF-β2) levels in... • PEDF levels were lower and MMP-2 and TGF-β2 levels were higher in cataracts. • The combined detection was valuable in evaluating cataract development. •... ABSTRACT Objective: To explore the changes of Pigment Epithelium-Derived Factor (PEDF), Matrix Metalloproteinase-2 (MMP-2), and Transforming Growth Factor-β2... |
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| SubjectTerms | Adult Aged Aqueous Humor Aqueous Humor - chemistry Aqueous Humor - metabolism Biomarkers - analysis Case-Control Studies Cataract Cataract - metabolism Eye Proteins - analysis Eye Proteins - metabolism Female Humans LOCS III Classification Male Matrix Metalloproteinase 2 - analysis Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase-2 MEDICINE, GENERAL & INTERNAL Middle Aged Nerve Growth Factors - analysis Nerve Growth Factors - metabolism Original Pigment Epithelial-Derived Factor Reference Values ROC Curve Serpins - analysis Serpins - metabolism Severity of Illness Index Transforming Growth Factor beta2 - analysis Transforming Growth Factor beta2 - metabolism Transforming Growth Factor-β2 |
| Title | Changes in PEDF, MMP-2, and TGF-β2 levels in the aqueous humor of cataract patients and their correlation with disease severity |
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