Genetic effects of PR toxin [a mycotoxin from Penicillium roqueforti] in eukaryotic microorganisms [Saccharomyces, Neurospora]

The genetic activity of PR toxin, a mycotoxin from Penicillium roqueforti, was studied in Saccharomyces cerevisiae and Neurospora crassa. The results show that PR toxin, without enzymic activation, causes gene conversion in S. cerevisiae strains D4 and D7, reverse mutation in S. cerevisiae strain D7...

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Bibliographic Details
Published inEnvironmental mutagenesis Vol. 1; no. 1; pp. 45 - 53
Main Authors Wei, R.D, Ong, T.M, Whong, W.Z, Frezza, D, Bronzetti, G, Zeiger, E
Format Journal Article
LanguageEnglish
Published United States 1979
Subjects
Chromosomes - drug effects
Crossing Over, Genetic
Mitosis
Mutagens
Mutation
Mycotoxins - pharmacology
Neurospora
Neurospora - genetics
Neurospora crassa - genetics
Penicillium
Recombination, Genetic
Saccharomyces
Saccharomyces cerevisiae - genetics
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Summary:The genetic activity of PR toxin, a mycotoxin from Penicillium roqueforti, was studied in Saccharomyces cerevisiae and Neurospora crassa. The results show that PR toxin, without enzymic activation, causes gene conversion in S. cerevisiae strains D4 and D7, reverse mutation in S. cerevisiae strain D7 and N. crassa strain N24, and mitotic crossing-over in S. cerevisiae strain D7, In the log phase cells of S. cerevisiae the effects are more pronounced at alkaline than at acid pH. The active site responsible for the genetic activity and toxicity is known. The carbonyl groups appear to play an important role in the biologic activity of this molecule.
Bibliography:Q
Q20
ISSN:0192-2521
1930-238X
DOI:10.1002/em.2860010111