Metals and Neurodegeneration

Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function...

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Bibliographic Details
Published inF1000 research Vol. 5; p. 366
Main Authors Chen, Pan, Miah, Mahfuzur Rahman, Aschner, Michael
Format Journal Article
LanguageEnglish
Published England Faculty of 1000 Ltd 2016
F1000Research
F1000 Research Ltd
Subjects
Cognitive Neurology & Dementia
Cognitive Neuroscience
Control of Gene Expression
Membranes & Sorting
Motor Systems
Movement Disorders
Neurobiology of Disease & Regeneration
Neurodevelopment
Neurogenetics
Neuronal & Glial Cell Biology
Parkinson's disease
Review
Toxicology
neurodegeneration
metal accumulation
Huntington’s disease
Alzheimer’s disease
Parkinson’s disease
neurological disorders
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Summary:Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes. Damage caused by metal accumulation may result in permanent injuries, including severe neurological disorders. Epidemiological and clinical studies have shown a strong correlation between aberrant metal exposure and a number of neurological diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillain-Barré disease, Gulf War syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and Wilson's disease. Here, we briefly survey the literature relating to the role of metals in neurodegeneration.
Bibliography:Competing interests: The authors declare that they have no competing interests.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.7431.1