Risk and outcomes of COVID‐19 in patients with multiple sclerosis

• Published in: European journal of neurology Vol. 28; no. 11; pp. 3712 - 3721
• Main Authors: Moreno‐Torres, Irene, Meca Lallana, Virginia, Costa‐Frossard, Lucienne, Oreja‐Guevara, Celia, Aguirre, Clara, Alba Suárez, Elda María, Gómez Moreno, Mayra, Borrega Canelo, Laura, Sabín Muñoz, Julia, Aladro, Yolanda, Cárcamo, Alba, Rodríguez García, Elena, Cuello, Juan Pablo, Monreal, Enric, Sainz de la Maza, Susana, Pérez Parra, Fernando, Valenzuela Rojas, Francisco, López de Silanes de Miguel, Carlos, Casanova, Ignacio, Martínez Gines, Maria Luisa, Blasco, Rosario, Orviz García, Aida, Villar‐Guimerans, Luisa María, Fernández‐Dono, Guillermo, Elvira, Víctor, Santiuste, Carmen, Espiño, Mercedes, García Domínguez, José Manuel
• Format: Journal Article
• Language: English
• Published: Oxford John Wiley & Sons, Inc 01.11.2021; John Wiley and Sons Inc
• Subjects: Confidence intervals; COVID-19; Data collection; Hospitalization; incidence; Infections; Intensive care; Multiple Sclerosis; Original; Patients; Serology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Spain; Viral diseases
• ISSN: 1351-5101; 1468-1331
• DOI: 10.1111/ene.14990

Background and purpose Limited information is available on incidence and outcomes of COVID‐19 in patients with multiple sclerosis (MS). This study investigated the risks of SARS‐CoV‐2 infection and COVID‐19‐related outcomes in patients with MS, and compared these with the general population. Methods A regional registry was created to collect data on incidence, hospitalization rates, intensive care unit admission, and death in patients with MS and COVID‐19. National government outcomes and seroprevalence data were used for comparison. The study was conducted at 14 specialist MS treatment centers in Madrid, Spain, between February and May 2020. Results Two‐hundred nineteen patients were included in the registry, 51 of whom were hospitalized with COVID‐19. The mean age ± standard deviation was 45.3 ± 12.4 years, and the mean duration of MS was 11.9 ± 8.9 years. The infection incidence rate was lower in patients with MS than the general population (adjusted incidence rate ratio = 0.78, 95% confidence interval [CI] = 0.70–0.80), but hospitalization rates were higher (relative risk = 5.03, 95% CI = 3.76–6.62). Disease severity was generally low, with only one admission to an intensive care unit and five deaths. Males with MS had higher incidence rates and risk of hospitalization than females. No association was found between the use of any disease‐modifying treatment and hospitalization risk. Conclusions Patients with MS do not appear to have greater risks of SARS‐CoV‐2 infection or severe COVID‐19 outcomes compared with the general population. The decision to start or continue disease‐modifying treatment should be based on a careful risk–benefit assessment. In this multicenter registry‐based cohort study, patients with multiple sclerosis did not have an increased risk of becoming infected with COVID‐19 compared with the general population, and were not more likely to have a severe outcome of COVID‐19 (i.e., admission to an intensive care unit or death). No relationship was found between the use of any disease‐modifying treatment and the development of severe COVID‐19 disease.