The predictive value of modified soluble urokinase plasminogen activator receptor (suPAR) with National Early Warning Score (NEWS) for mortality in emergency elderly patients in Japan: a prospective pilot study

• Published in: Acute medicine & surgery Vol. 10; no. 1; pp. e840 - n/a
• Main Authors: Mitsunaga, Toshiya, Ohtaki, Yuhei, Seki, Yutaka, Mashiko, Kunihiro, Uzura, Masahiko, Okuno, Kenji, Takeda, Satoshi
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2023; John Wiley and Sons Inc; Wiley
• Subjects: Blood; Cardiology; Comorbidity; Creatinine; Elderly patients; Emergency medical care; Endocrinology; Hospitals; Mortality; Nephrology; NEWS; Older people; Original; Patients; Pilot projects; prognosis; Pulmonology; Student's t-test; suPAR; Vital signs; Denmark; Japan; mortality; suPAR; Elderly patients; prognosis; NEWS
• ISSN: 2052-8817; 2052-8817
• DOI: 10.1002/ams2.840

Aim The aim of this study is to evaluate the ability of soluble urokinase plasminogen activator receptor (suPAR) and modified suPAR with National Early Warning Score (NEWS) for detecting mortality in elderly emergency patients who are older than 70 years. Methods This is a secondary analysis of our previous study, which was a single‐center prospective pilot study, carried out for 21 months in the emergency department of a secondary emergency institution in Japan. This study was carried out between September 16, 2020, and June 21, 2022. The study included all patients without trauma aged 70 years or older who presented to the emergency department. Discrimination was assessed by plotting the receiver‐operating characteristic curve and calculating the area under the receiver‐operating characteristic curve (AUC). Results During the study period, 47 eligible older patients were included, among which 8 (17.0%) patients died. The median suPAR was significantly lower in the survivor's group than in the nonsurvivor's group (P < 0.01). For suPAR, the AUC for the prediction of mortality was 0.805 (95% confidence interval 0.633–0.949, P < 0.001). The AUC of modified suPAR with NEWS for mortality was higher than that of suPAR [0.865 (95% confidence interval 0.747–0.958, P < 0.001)]. Conclusion Our single‐center study has demonstrated the high utility of modified suPAR with NEWS as a predictive tool of mortality in elderly emergency patients. Evidence from multicenter studies is needed for introducing modified suPAR with NEWS in the emergency department setting. The aim of this study is to evaluate the ability of modified suPAR with National Early Warning Score (NEWS) for detecting mortality in elderly emergency patients who are older than 70 years. Our single‐center study has demonstrated the high utility of modified suPAR with NEWS as a predictive tool of mortality in elderly emergency patients.