Mechanical ventricular assistance in heart failure: pathology of the cardiac apex removed during device implantation

Abstract Background Ventricular assistance device (VAD) implantation provides large ventricular core biopsies available for pathological assessment. We present here the pathological data from 60 apex removed during a 7-year-period in a single institution. Results The most frequent specific lesions w...

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Published inCardiovascular pathology Vol. 19; no. 2; pp. 112 - 116
Main Authors Cazes, Aurélie, Van Huyen, Jean-Paul Duong, Fornes, Paul, Amrein, Catherine, Guillemain, Romain, Grinda, Jean-Michel, Bruneval, Patrick
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2010
Subjects
Adolescent
Adult
Cardiomyopathies
Cardiomyopathy, Hypertrophic - complications
Cardiomyopathy, Hypertrophic - pathology
Cardiomyopathy, Hypertrophic - surgery
Child
Female
Heart Diseases - complications
Heart Diseases - pathology
Heart Diseases - surgery
Heart Failure - etiology
Heart Failure - pathology
Heart Failure - surgery
Heart failure therapy
Heart Ventricles - pathology
Heart Ventricles - surgery
Heart-Assist Devices
Hemochromatosis - complications
Hemochromatosis - pathology
Hemochromatosis - surgery
Humans
Male
Middle Aged
Myocardial Infarction - complications
Myocardial Infarction - pathology
Myocardial Infarction - surgery
Myocarditis
Myocarditis - complications
Myocarditis - pathology
Myocarditis - surgery
Myocardium - pathology
Pathology
Prosthesis Implantation
Ventricular assistance devices
Young Adult
Myocarditis
Cardiomyopathies
Heart failure therapy
Ventricular assistance devices
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Summary:Abstract Background Ventricular assistance device (VAD) implantation provides large ventricular core biopsies available for pathological assessment. We present here the pathological data from 60 apex removed during a 7-year-period in a single institution. Results The most frequent specific lesions were ischemic myocardial damage. Nonspecific pathological features were quite as frequently observed and correspond either to dilated cardiomyopathies, chronic ischemic cardiopathies, or miscellaneous conditions. Myocarditis represented 10 out of the 60 cases. The pathological data changed the clinical diagnosis in four cases: 1 case of juvenile hemochromatosis featuring as myocarditis and three cases of myocarditis featuring as dilated cardiomyopathies. Conclusion Apex pathological analysis provides definite diagnosis and contributes to determine the cases which the cardiac disease have a possibility to recover under VAD.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1054-8807
1879-1336
DOI:10.1016/j.carpath.2008.10.013