Dietary fish oil–induced changes in the distribution ofα-tocopherol, retinol, andβ-carotene in plasma, red blood cells, and platelets: modulation by vitamin E
Healthy men (ages 24–57 y) were fed a controlled basal diet supplemented with 15 g/d of placebo oil (PO) for 10 wk followed by 15 g/d of fish-oil concentrate (FO) (fortified with 15 mg all-rac-tocopherol) for 10 wk without additionalα-tocopherol and the last 8 wk with 200 mgα-tocopherol/d (FO + E)....
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Published in | The American journal of clinical nutrition Vol. 58; no. 1; pp. 98 - 102 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
Elsevier Inc
01.07.1993
American Society for Clinical Nutrition |
Subjects | |
Online Access | Get full text |
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Summary: | Healthy men (ages 24–57 y) were fed a controlled basal diet supplemented with 15 g/d of placebo oil (PO) for 10 wk followed by 15 g/d of fish-oil concentrate (FO) (fortified with 15 mg all-rac-tocopherol) for 10 wk without additionalα-tocopherol and the last 8 wk with 200 mgα-tocopherol/d (FO + E). Compared with PO, FO raised plasma malondialdehyde; loweredα-tocopherol in plasma, red blood cells, and platelets; and raised plasma and plateletβ-carotene. Supplementation with additionalα-tocopherol (FO + E) not only restored tocopherol concentrations but also reversed the rise inβ-carotene. The response in retinol, particularly in platelets, showed an inverse relationship toβ-carotene,α-tocopherol exhibiting a modulating effect on these changes. From these observations it is postulated that platelets may be a significant extraintestinal site of retinol formation fromβ-carotene. |
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Bibliography: | S20 9423954 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0002-9165 1938-3207 |
DOI: | 10.1093/ajcn/58.1.98 |