Dietary fish oil–induced changes in the distribution ofα-tocopherol, retinol, andβ-carotene in plasma, red blood cells, and platelets: modulation by vitamin E

• Published in: The American journal of clinical nutrition Vol. 58; no. 1; pp. 98 - 102
• Main Authors: Nair, PP, Judd, JT, Berlin, E, Taylor, PR, Shami, S, Sainz, E, Bhagavan, HN
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.07.1993; American Society for Clinical Nutrition
• Subjects: ACEITES DE PESCADO; ACIDE GRAS; ACIDE GRAS POLYINSATURE; ACIDOS GRASOS; ACIDOS GRASOS POLIINSATURADOS; ADDITIF ALIMENTAIRE; ADITIVOS ALIMENTARIOS; Adult; ALDEHIDOS; ALDEHYDE; beta Carotene; Biological and medical sciences; Blood Platelets - metabolism; CAROTENOIDE; CAROTENOIDES; Carotenoids - blood; DIETA; Dietary Fats - administration & dosage; Diseases of the cardiovascular system; ERITROCITOS; ERYTHROCYTE; Erythrocytes - metabolism; EXPERIMENTACION; EXPERIMENTATION; fish oil; Fish Oils - administration & dosage; HOMBRES; HOMME; HUILE DE POISSON; Humans; Male; MARYLAND; Medical sciences; Middle Aged; n−3 Polyunsaturated fatty acids; PLASMA SANGUIN; PLASMA SANGUINEO; platelets; polyunsaturated fatty acids; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); red blood cells; REGIME ALIMENTAIRE; RETINOL; THROMBOCYTE; TOCOFEROLES; TOCOPHEROL; TROMBOCITOS; vitamin A; Vitamin A - blood; vitamin E; Vitamin E - blood; Vitamin E - pharmacology; VITAMINA E; VITAMINE E; α-tocopherol; β-carotene; retinol; red blood cells; n−3 Polyunsaturated fatty acids; vitamin A; fish oil; vitamin E; polyunsaturated fatty acids; β-carotene; platelets; α-tocopherol; Human; Prevention; Biochemical analysis; Diet therapy; Treatment; Cardiovascular disease; Fish oil; Biological activity; Blood
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/58.1.98

Healthy men (ages 24–57 y) were fed a controlled basal diet supplemented with 15 g/d of placebo oil (PO) for 10 wk followed by 15 g/d of fish-oil concentrate (FO) (fortified with 15 mg all-rac-tocopherol) for 10 wk without additionalα-tocopherol and the last 8 wk with 200 mgα-tocopherol/d (FO + E). Compared with PO, FO raised plasma malondialdehyde; loweredα-tocopherol in plasma, red blood cells, and platelets; and raised plasma and plateletβ-carotene. Supplementation with additionalα-tocopherol (FO + E) not only restored tocopherol concentrations but also reversed the rise inβ-carotene. The response in retinol, particularly in platelets, showed an inverse relationship toβ-carotene,α-tocopherol exhibiting a modulating effect on these changes. From these observations it is postulated that platelets may be a significant extraintestinal site of retinol formation fromβ-carotene.