Epitope-defined Monoclonal Antibodies against Multiplexin Collagens Demonstrate that Type XV and XVIII Collagens are Expressed in Specialized Basement Membranes

• Published in: Cell Structure and Function Vol. 27; no. 1; pp. 9 - 20
• Main Authors: Tomono, Yasuko, Naito, Ichiro, Ando, Kaori, Yonezawa, Tomoko, Sado, Yoshikazu, Hirakawa, Satoshi, Arata, Jirô, Okigaki, Tohru, Ninomiya, Yoshifumi
• Format: Journal Article
• Language: English
• Published: Japan Japan Society for Cell Biology 01.02.2002; Japan Science and Technology Agency
• Subjects: Antibodies, Monoclonal - immunology; basement membrane; Basement Membrane - metabolism; Capillaries - metabolism; Capillaries - ultrastructure; capillary; Collagen - immunology; Collagen - metabolism; Collagen Type XVIII; Epithelial Cells - metabolism; Epithelial Cells - ultrastructure; Epitopes - immunology; Humans; Immunohistochemistry; Muscles - metabolism; Muscles - ultrastructure; smooth muscle cell; Tissue Distribution; type XV collagen; type XVIII collagen

Type XV and type XVIII collagens are classified as part of multiplexin collagen superfamily and their C-terminal parts, endostatin and restin, respectively, have been shown to be anti-angiogenic in vivo and in vitro. The α1(XV) and α1(XVIII) collagen chains are reported to be localized mainly in the...