International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative

• Published in: Nature reviews. Rheumatology Vol. 19; no. 12; p. 805
• Main Authors: Oldroyd, Alexander G S, Callen, Jeffrey P, Chinoy, Hector, Chung, Lorinda, Fiorentino, David, Gordon, Patrick, Machado, Pedro M, McHugh, Neil, Selva-O'Callaghan, Albert, Schmidt, Jens, Tansley, Sarah L, Vleugels, Ruth Ann, Werth, Victoria P, Aggarwal, Rohit
• Format: Journal Article
• Language: English
• Published: United States 01.12.2023
• Subjects: Adult; Autoantibodies; Early Detection of Cancer; Humans; Myositis - complications; Myositis - diagnosis; Neoplasms - diagnosis; Positron Emission Tomography Computed Tomography
• ISSN: 1759-4804
• DOI: 10.1038/s41584-023-01045-w

Adult-onset idiopathic inflammatory myopathy (IIM) is associated with an increased cancer risk within the 3 years preceding and following IIM onset. Evidence- and consensus-based recommendations for IIM-associated cancer screening can potentially improve outcomes. This International Guideline for IIM-Associated Cancer Screening provides recommendations addressing IIM-associated cancer risk stratification, cancer screening modalities and screening frequency. The international Expert Group formed a total of 18 recommendations via a modified Delphi approach using a series of online surveys. First, the recommendations enable an individual patient's IIM-associated cancer risk to be stratified into standard, moderate or high risk according to the IIM subtype, autoantibody status and clinical features. Second, the recommendations outline a 'basic' screening panel (including chest radiography and preliminary laboratory tests) and an 'enhanced' screening panel (including CT and tumour markers). Third, the recommendations advise on the timing and frequency of screening via basic and enhanced panels, according to risk status. The recommendations also advise consideration of upper or lower gastrointestinal endoscopy, nasoendoscopy and F-FDG PET-CT scanning in specific patient populations. These recommendations are aimed at facilitating earlier IIM-associated cancer detection, especially in those who are at a high risk, thus potentially improving outcomes, including survival.