Design and development of a portable low-cost QCM-based system for liquid biosensing

Quartz crystal microbalance (QCM) is a versatile sensing platform that has gained increasing attention for its use in bioapplications due to its high sensitivity, real-time measurement capabilities, and label-free detection. This article presents a portable QCM system for liquid biosensing that uses...

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Bibliographic Details
Published inBiomedical microdevices Vol. 26; no. 1; p. 11
Main Authors Adel, Mohamed, Allam, Ahmed, Sayour, Ashraf E., Ragai, Hani F., Umezu, Shinjiro, Fath El-Bab, Ahmed M. R.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2024
Springer Nature B.V
Subjects
Biological and Medical Physics
Biomedical Engineering and Bioengineering
Biophysics
Biosensors
Design
Diameters
Engineering
Engineering Fluid Dynamics
Frequency measurement
Glycerol
Low cost
Nanotechnology
Portability
Quartz crystal microbalance
Quartz Crystal Microbalance Techniques
Quartz crystals
Sensitivity
Sensitivity analysis
Temperature
Temperature control
Viscosity
Peltier module
Hartley oscillator
QCM
Flow cell
Micropump
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Summary:Quartz crystal microbalance (QCM) is a versatile sensing platform that has gained increasing attention for its use in bioapplications due to its high sensitivity, real-time measurement capabilities, and label-free detection. This article presents a portable QCM system for liquid biosensing that uses a modified Hartley oscillator to drive 14 mm-diameter commercial QCM sensors. The system is designed to be low-cost, easy to use, and highly sensitive, making it ideal for various bioapplications. A new flow cell design to deliver samples to the surface of the sensor has been designed, fabricated, and tested. For portability and miniaturization purposes, a micropump-based pumping system is used in the current system. The system has a built-in temperature controller allowing for accurate frequency measurements. In addition, the system can be used in benchtop mode. The capability of the present system to be used in liquid biosensing is demonstrated through an experimental test for sensitivity to changes in the viscosity of glycerol samples. It was found to have a sensitivity of 263.51 Hz/mPa.s using a 10 MHz QCM sensor. Future work regarding potential applications was suggested. Graphical Abstract
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ISSN:1387-2176
1572-8781
DOI:10.1007/s10544-024-00696-0