Thermal characterization of raw material pentoxifylline using thermoanalytical techniques and Pyr-GC/MS

• Published in: Journal of thermal analysis and calorimetry Vol. 106; no. 3; pp. 763 - 766
• Main Authors: de Oliveira, Agna Hélia, de Moura, Elisana Afonso, Pinto, Márcia Ferraz, Procópio, José Valdilânio Virgulino, de Souza, Valmir Gomes, de Souza, Fábio Santos, Macêdo, Rui Oliveira
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2011; Springer
• Subjects: Analytical Chemistry; Biological and medical sciences; Cardiovascular system; Chemical properties; Chemistry; Chemistry and Materials Science; Inorganic Chemistry; Mass spectrometry; Measurement Science and Instrumentation; Medical sciences; Methods; Pentoxifylline; Pharmacology. Drug treatments; Physical Chemistry; Polymer Sciences; Pyrolysis; Raw materials; Vasodilator agents. Cerebral vasodilators; Pentoxifylline; Pyrolysis; Thermal analysis; Pharmaceutical analysis; Purine derivatives; 3',5'-Cyclic-nucleotide phosphodiesterase; Chemical analysis; Vasodilator agent; Enzyme; Coupled method; Enzyme inhibitor; Esterases; Raw materials; Phosphoric diester hydrolases; Gas chromatography; Hydrolases; Xanthine derivatives; Degradation product; Mass spectrometry
• ISSN: 1388-6150; 1588-2926; 1572-8943
• DOI: 10.1007/s10973-011-1839-4

This work studied the thermal characterization of the pentoxifylline raw material through thermoanalytical techniques (TG, DSC, DSC-photovisual) and analysis of degradation products by Pyr-GC/MS. The picture obtained with DSC-photovisual showed the total vaporization of pentoxifylline at 230.0 °C. The TG dynamical curve presented only one step for the loss of mass evidencing to be a kinetic process of zero order reaction. The pyrograms obtained for pentoxifylline sample in the solid state and solution in the temperatures of 250.0, 300.0, and 400.0 °C, showed only one peak identifying the pentoxifylline.