Maturation of Fish Erythrocytes Coincides with Changes in their Morphology, Enhanced Ability to Interact with Candida albicans and Release of Cytokine-Like Factors Active Upon Autologous Macrophages

Erythrocytes from the rainbow trout Salmo gairdneri Richardson (Salmo g.R.) were classified into immature and mature populations, respectively, by measuring longitudinal diameters. More elongated fish erythrocytes (FE), classified as mature cells, were those interacting with Candida albicans (CA) in...

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Published inImmunopharmacology and immunotoxicology Vol. 26; no. 4; pp. 573 - 585
Main Authors Passantino, L., Altamura, M., Cianciotta, A., Jirillo, F., Ribaud, M. R., Jirillo, E., Passantino, G. F.
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 2004
Taylor & Francis
Subjects
Animals
Candida albicans
Candida albicans - immunology
Erythrocytes
Erythrocytes - immunology
Erythrocytes - metabolism
Fish
Kidney - cytology
Kidney - immunology
Macrophage Migration-Inhibitory Factors - immunology
Macrophage Migration-Inhibitory Factors - metabolism
Macrophages
Macrophages - immunology
Macrophages - metabolism
Oncorhynchus mykiss
Oncorhynchus mykiss - blood
Oncorhynchus mykiss - immunology
Phagocytosis - immunology
Rosette Formation
Salmo
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Summary:Erythrocytes from the rainbow trout Salmo gairdneri Richardson (Salmo g.R.) were classified into immature and mature populations, respectively, by measuring longitudinal diameters. More elongated fish erythrocytes (FE), classified as mature cells, were those interacting with Candida albicans (CA) in a higher frequency in terms of either binding to the fungus or its intracellular engulfment. At the same time, in the rosetting phenomenon more elongated mature FE surrounded macrophages (MØ) phagocytosing CA. Finally, FE activated by CA released in the supernatants cytokine-like factors able to modulate MØ functions. In particular, these active supernatants were analyzed for their capacity to inhibit MØ migration Macrophage Inhibition Factor (MIF) activity and enhance MØ phagocytosis. Both activities were detected in supernatants from CA stimulated FE but not in control supernatants. MIF activity could play a role in the accumulation of MØ in the context of functional rosettes, while the factor enhancing MØ phagocytosis could promote clearance of CA in a more efficacious way.
Bibliography:ObjectType-Article-1
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ISSN:0892-3973
1532-2513
DOI:10.1081/IPH-200042323