Know Your Model: The role of sex in phenotype penetrance and severity

There’s growing evidence that sex-based differences can influence phenotypes beyond those directly related to the reproductive system; to fully understand a gene’s function, researchers should consider both male and female subjects.

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Bibliographic Details
Published inLab animal Vol. 49; no. 9; pp. 239 - 240
Main Authors Bello, Susan M., Perry, Michelle N., Smith, Cynthia L.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.09.2020
Nature Publishing Group
Subjects
631/1647/334/1874/345
631/208
Analysis
Animal Models
Animals
Biomedical and Life Sciences
Comment
Dimorphism (Biology)
Female
Gene mutations
Genetic aspects
Life Sciences
Male
Mutation
Observations
Penetrance
Phenotype
Sex Factors
Veterinary Medicine/Veterinary Science
United States
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Summary:There’s growing evidence that sex-based differences can influence phenotypes beyond those directly related to the reproductive system; to fully understand a gene’s function, researchers should consider both male and female subjects.
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ISSN:0093-7355
1548-4475
1548-4475
DOI:10.1038/s41684-020-0616-z