Influenza antiviral treatment in spinal cord injury patients, 2007-2010

• Published in: The journal of spinal cord medicine Vol. 38; no. 1; pp. 48 - 56
• Main Authors: Evans, Charlesnika T., Rogers, Thea J., Goldstein, Barry, Weaver, Frances M., LaVela, Sherri L.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2015; Maney Publishing
• Subjects: Adult; Aged; Antiviral Agents - therapeutic use; Antivirals; Appropriate prescribing; Drug Prescriptions - statistics & numerical data; Female; Humans; Influenza; Influenza, Human - complications; Influenza, Human - drug therapy; Influenza, Human - epidemiology; Male; Middle Aged; Spinal Cord Injuries - complications; Spinal Cord Injuries - epidemiology; Spinal cord injury; Spinal cord injury; Influenza; Antivirals; Appropriate prescribing
• ISSN: 1079-0268; 2045-7723
• DOI: 10.1179/2045772314Y.0000000237

Objective This study assessed antiviral medication use for treatment of influenza-like illness (ILI) in Veterans with spinal cord injury or disorder (SCI/D) and examined whether antiviral prescribing improved over time. Design Retrospective cohort study of Department of Veterans Affairs (VA) facilities. Participants Veterans with SCI/D and matched non-SCI/D controls (matched by facility and date of visit/admission) who were diagnosed by a clinician with ILI during the period 1 October 2007 to 31 May 2010. Main outcome measures Antiviral receipt and appropriateness were examined. Appropriate antiviral prescribing was defined as patients who received an antiviral medication within 2 days of collection of a sample for diagnostic testing or within 2 days of symptom onset. Results We identified 101 influenza visits/admissions for veterans with SCI/D and 123 for controls. Antiviral prescribing for Veterans with SCI/D increased from 37.1% in 2007/2008 to 67.6% in 2009/2010 (P = 0.01) and appropriate antiviral prescribing increased from 20.0 to 41.2% (P = 0.05). Predictors of antiviral prescribing included being treated in the 2009/2010 influenza season (vs. 2007/2008) and having a cough. Fever, aches/myalgia, or a positive influenza test was associated with appropriate antiviral treatment. SCI/D was an independent predictor of receiving antiviral treatment (adjusted odds ratio = 1.16, 95% confidence interval 1.04-1.29), but having SCI/D was not associated with receiving appropriate treatment. Conclusions Influenza antiviral prescribing increased over time and in a larger proportion in veterans with SCI/D (vs. controls). This suggests that providers treating patients with SCI/D recognize treatment guidelines and their importance in a high-risk population. Continued efforts are needed to improve appropriate influenza antiviral prescribing.