Humanized mice as preclinical models for myeloid malignancies

• Published in: Biochemical pharmacology Vol. 174; p. 113794
• Main Authors: Gbyli, Rana, Song, Yuanbin, Halene, Stephanie
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.04.2020
• Subjects: Cytokine humanization; Humanized mice; Immunodeficient mouse models; Myeloid malignancy; Pre-clinical studies; Xenotransplantation; Cytokine humanization; Immunodeficient mouse models; Pre-clinical studies; Humanized mice; Xenotransplantation; Myeloid malignancy

[Display omitted] Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been pl...