Humanized mice as preclinical models for myeloid malignancies

[Display omitted] Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been pl...

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Bibliographic Details
Published inBiochemical pharmacology Vol. 174; p. 113794
Main Authors Gbyli, Rana, Song, Yuanbin, Halene, Stephanie
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 01.04.2020
Subjects
Cytokine humanization
Humanized mice
Immunodeficient mouse models
Myeloid malignancy
Pre-clinical studies
Xenotransplantation
Cytokine humanization
Immunodeficient mouse models
Pre-clinical studies
Humanized mice
Xenotransplantation
Myeloid malignancy
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Summary:[Display omitted] Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been placed to advance and optimize humanized mice to support the engraftment, differentiation, and maintenance of hematopoietic stem cells (HSCs) and the human hematological system in order to broaden the scope of applications of such models. This review covers the background of humanized mice, how they are used as platforms to model myeloid malignancies, and the various current and potential approaches to further enhance their utilization in biomedical research.
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ISSN:0006-2952
1873-2968
1873-2968
DOI:10.1016/j.bcp.2020.113794