Humanized mice as preclinical models for myeloid malignancies
[Display omitted] Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been pl...
Saved in:
| Published in | Biochemical pharmacology Vol. 174; p. 113794 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Inc
01.04.2020
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | [Display omitted]
Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been placed to advance and optimize humanized mice to support the engraftment, differentiation, and maintenance of hematopoietic stem cells (HSCs) and the human hematological system in order to broaden the scope of applications of such models. This review covers the background of humanized mice, how they are used as platforms to model myeloid malignancies, and the various current and potential approaches to further enhance their utilization in biomedical research. |
|---|---|
| AbstractList | [Display omitted]
Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been placed to advance and optimize humanized mice to support the engraftment, differentiation, and maintenance of hematopoietic stem cells (HSCs) and the human hematological system in order to broaden the scope of applications of such models. This review covers the background of humanized mice, how they are used as platforms to model myeloid malignancies, and the various current and potential approaches to further enhance their utilization in biomedical research. Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been placed to advance and optimize humanized mice to support the engraftment, differentiation, and maintenance of hematopoietic stem cells (HSCs) and the human hematological system in order to broaden the scope of applications of such models. This review covers the background of humanized mice, how they are used as platforms to model myeloid malignancies, and the various current and potential approaches to further enhance their utilization in biomedical research.Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been placed to advance and optimize humanized mice to support the engraftment, differentiation, and maintenance of hematopoietic stem cells (HSCs) and the human hematological system in order to broaden the scope of applications of such models. This review covers the background of humanized mice, how they are used as platforms to model myeloid malignancies, and the various current and potential approaches to further enhance their utilization in biomedical research. Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been placed to advance and optimize humanized mice to support the engraftment, differentiation, and maintenance of hematopoietic stem cells (HSCs) and the human hematological system in order to broaden the scope of applications of such models. This review covers the background of humanized mice, how they are used as platforms to model myeloid malignancies, and the various current and potential approaches to further enhance their utilization in biomedical research. |
| ArticleNumber | 113794 |
| Author | Halene, Stephanie Song, Yuanbin Gbyli, Rana |
| Author_xml | – sequence: 1 givenname: Rana surname: Gbyli fullname: Gbyli, Rana – sequence: 2 givenname: Yuanbin surname: Song fullname: Song, Yuanbin – sequence: 3 givenname: Stephanie orcidid: 0000-0002-2737-9810 surname: Halene fullname: Halene, Stephanie email: stephanie.halene@yale.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31926939$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kMtKAzEUQIMotlY_wI3M0k1rHtPJBHEhxRcU3Og6ZJIbSckkNZkK-vWmtN24cJVcOOfCPWfoOMQACF0SPCOYNDerWafXM4ppmQnjoj5CY9JyNqWiaY_RGGPclP-cjtBZzqvt2DbkFI0YEbQRTIzR3fOmV8H9gKl6p6FSuVon0N4Fp5Wv-mjA58rGVPXf4KMrmPLuI6igHeRzdGKVz3Cxfyfo_fHhbfE8Xb4-vSzul1NdEzFMjaVUtbS2tW6x5WJuatNYrgjuGiOEtgJzZcncaNZoMLyjVnSsmzPSdi3TwCboerd3neLnBvIge5c1eK8CxE2WlDGOOWFtXdCrPbrpejBynVyv0rc8nFwAvgN0ijknsFK7QQ0uhiEp5yXBchtXrmSJK7dx5S5uMckf87D8P-d255SM8OUgyVzChXKlK5kHaaL7x_4FYEaREA |
| CitedBy_id | crossref_primary_10_1021_acs_bioconjchem_1c00036 crossref_primary_10_1038_s41375_024_02181_2 crossref_primary_10_3390_bioengineering8050067 crossref_primary_10_1111_exd_14270 crossref_primary_10_1111_bjh_20023 crossref_primary_10_1016_j_exphem_2020_11_008 crossref_primary_10_3390_ijms22073632 crossref_primary_10_3389_fimmu_2021_643852 crossref_primary_10_1038_s41375_021_01327_w crossref_primary_10_3389_fimmu_2023_1277987 crossref_primary_10_1016_j_exphem_2021_12_395 crossref_primary_10_3892_ijmm_2024_5455 |
| Cites_doi | 10.1016/j.stem.2014.02.014 10.1016/j.stemcr.2014.12.005 10.1371/journal.pone.0186035 10.1038/301527a0 10.1016/j.jaci.2016.01.049 10.1182/blood.V87.6.2459.bloodjournal8762459 10.1073/pnas.1019682108 10.1016/S0145-2126(02)00221-7 10.1038/nbt.2858 10.1182/blood-2001-12-0207 10.1002/0471142735.im1521s81 10.1038/s41467-018-08166-x 10.1038/nm.3647 10.1097/MOH.0000000000000112 10.1038/leu.2010.156 10.4049/jimmunol.174.10.6477 10.1182/blood-2015-12-689356 10.1016/j.leukres.2009.03.005 10.1038/ni1527 10.1182/blood-2010-09-309179 10.1038/sj.leu.2403222 10.3389/fimmu.2016.00333 10.1073/pnas.89.8.3290 10.1038/nmeth.1309 10.1016/j.clim.2009.12.008 10.1038/leu.2010.158 10.1038/sj.leu.2403649 10.1182/bloodadvances.2017004903 10.1089/scd.2015.0289 10.1038/nm.4103 10.1182/blood-2017-01-763219 10.1016/j.immuni.2018.03.024 10.1200/JCO.2017.72.6745 10.1002/jcb.26002 10.1182/blood-2010-08-301507 10.1146/annurev-immunol-032712-095921 10.1111/imm.12290 10.3324/haematol.2017.183202 10.1101/cshperspect.a008250 10.1073/pnas.1019524108 10.1182/blood-2016-04-709584 10.1111/j.1365-2141.1994.tb04904.x 10.1172/JCI89364 10.1182/blood-2013-08-518886 10.1038/nature25022 10.1101/pdb.top073585 10.1182/blood-2003-09-3192 10.1182/blood-2016-03-643544 10.1158/2159-8290.CD-18-0140 10.1038/nri3311 10.1155/2016/1625015 10.1038/leu.2013.372 10.1182/bloodadvances.2018023887 10.1016/j.ccr.2010.03.011 10.3389/fgene.2015.00290 10.3324/haematol.2015.139394 10.1073/pnas.1705301114 10.1182/blood-2014-08-550483 10.1053/j.gastro.2012.09.057 10.1016/j.stemcr.2016.07.002 10.1056/NEJMra1406184 10.1016/j.immuni.2007.05.001 10.1056/NEJMoa1516192 10.1182/blood-2012-06-440354 10.3324/haematol.2010.027557 10.1016/j.it.2011.04.005 10.1016/j.stem.2014.06.001 10.1111/j.1582-4934.2008.00347.x 10.1038/bcj.2014.89 10.1152/physiolgenomics.90242.2008 10.1182/blood-2015-10-676452 10.1038/cmi.2012.2 10.1182/blood-2013-09-381665 10.1016/j.canep.2016.03.011 10.1016/j.stemcr.2017.08.018 10.1182/blood-2010-12-326926 10.1182/blood.V91.7.2406 10.1016/j.stemcr.2016.08.005 |
| ContentType | Journal Article |
| Copyright | 2020 Elsevier Inc. Copyright © 2020 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2020 Elsevier Inc. – notice: Copyright © 2020 Elsevier Inc. All rights reserved. |
| DBID | AAYXX CITATION NPM 7X8 |
| DOI | 10.1016/j.bcp.2020.113794 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1873-2968 |
| ExternalDocumentID | 31926939 10_1016_j_bcp_2020_113794 S0006295220300046 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M -~X .55 .GJ .HR .~1 0R~ 1B1 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO AAYJJ ABFNM ABFRF ABJNI ABLJU ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACNCT ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AFFNX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AHPSJ AI. AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HZ~ IH2 IHE J1W K-O KOM L7B LPU M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SDF SDG SDP SES SEW SPCBC SPT SSP SSZ T5K TEORI TWZ VH1 WH7 WUQ X7M ZA5 ZGI ZXP ~G- AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH NPM 7X8 |
| ID | FETCH-LOGICAL-c419t-df22a824f4c80f795d4d6f7a10b6d99cf907af15dc36ced7b2f9b3b5318b83ce3 |
| IEDL.DBID | .~1 |
| ISSN | 0006-2952 1873-2968 |
| IngestDate | Thu Jul 10 17:57:48 EDT 2025 Thu Apr 03 06:52:36 EDT 2025 Tue Jul 01 03:01:27 EDT 2025 Thu Apr 24 22:57:06 EDT 2025 Fri Feb 23 02:49:09 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Cytokine humanization Immunodeficient mouse models Pre-clinical studies Humanized mice Xenotransplantation Myeloid malignancy |
| Language | English |
| License | Copyright © 2020 Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c419t-df22a824f4c80f795d4d6f7a10b6d99cf907af15dc36ced7b2f9b3b5318b83ce3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0002-2737-9810 |
| PMID | 31926939 |
| PQID | 2337071384 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2337071384 pubmed_primary_31926939 crossref_citationtrail_10_1016_j_bcp_2020_113794 crossref_primary_10_1016_j_bcp_2020_113794 elsevier_sciencedirect_doi_10_1016_j_bcp_2020_113794 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | April 2020 2020-04-00 2020-Apr 20200401 |
| PublicationDateYYYYMMDD | 2020-04-01 |
| PublicationDate_xml | – month: 04 year: 2020 text: April 2020 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Biochemical pharmacology |
| PublicationTitleAlternate | Biochem Pharmacol |
| PublicationYear | 2020 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Chen, Fan, Zou, Zhang, He, Shu (b0390) 2017; 9 Zhang, Duan, Zhao (b0100) 2009; 13 Pearson, Greiner, Shultz (b0065) 2008 Ramsey, Fischer, Lee, Gorska, Arrate, Fuller (b0230) 2018; 8 Wunderlich, Chou, Link, Mizukawa, Perry, Carroll (b0140) 2010; 24 Abarrategi, Foster, Hamilton, Mian, Passaro, Gribben (b0300) 2017; 127 Krevvata, Shan, Zhou, Dos Santos, Habineza Ndikuyeze, Secreto (b0210) 2018; 103 Zhang, Strauss, Chu, Li, Ho, Shiang (b0320) 2010; 17 Rieger, Schroeder (b0010) 2012; 4 Shultz, Lyons, Burzenski, Gott, Chen, Chaleff (b0045) 2005; 174 Medyouf, Mossner, Jann, Nolte, Raffel, Herrmann (b0290) 2014; 14 Bryce, Falahati, Kenney, Leung, Bebbington, Tomasevic (b0155) 2016; 138 Cazzola, Della Porta, Malcovati (b0240) 2013; 122 Rongvaux, Willinger, Martinek, Strowig, Gearty, Teichmann (b0165) 2014; 32 Haferlach, Winkemann, Loffler, Schoch, Gassmann, Fonatsch (b0225) 1996; 87 Wang, Lapidot, Cashman, Doedens, Addy, Sutherland (b0330) 1998; 91 Yoshimi, Balasis, Vedder, Feldman, Ma, Zhang (b0345) 2017; 130 Ellegast, Rauch, Kovtonyuk, Muller, Wagner, Saito (b0220) 2016; 128 Leonard, Martin, Roboz (b0190) 2017; 35 Muguruma, Matsushita, Yahata, Yumino, Tanaka, Miyachi (b0255) 2011; 96 Kwong, Brown, Barclay, Hatherley (b0090) 2014; 143 Saito, Ellegast, Rafiei, Song, Kull, Heikenwalder (b0170) 2016 Shultz, Brehm, Garcia-Martinez, Greiner (b0055) 2012; 12 Ito, Takahashi, Katano, Ito (b0110) 2012; 9 Rathinam, Poueymirou, Rojas, Murphy, Valenzuela, Yancopoulos (b0125) 2011; 118 Locatelli, Niemeyer (b0315) 2015; 125 Wei, Frenette (b0015) 2018; 48 Leon, Dupuis, Gachet, Lanza (b0030) 2016; 101 Shultz, Goodwin, Ishikawa, Hosur, Lyons, Greiner (b0070) 2014; 2014 Ito, Hiramatsu, Kobayashi, Suzue, Kawahata, Hioki (b0050) 2002; 100 Zhang, He, Selimoglu-Buet, Jego, Morabito, Willekens (b0350) 2017; 1 Tohyama, Tsutani, Ueda, Nakamura, Yoshida (b0245) 1994; 87 Enciso, Mendoza, Pelayo (b0020) 2015; 6 Drexler, Dirks, Macleod (b0250) 2009; 33 Prochazka, Gaskins, Shultz, Leiter (b0075) 1992; 89 Padron, Steensma (b0310) 2015; 22 Sippel, Radtke, Olsen, Kiem, Rongvaux (b0160) 2019; 3 Arber, Orazi, Hasserjian, Thiele, Borowitz, Le Beau (b0195) 2016; 127 Sontakke, Jaques, Vellenga, Schuringa (b0305) 2016; 2016 McIntosh, Brown, Duffin, Maufort, Vereide, Slukvin (b0365) 2015; 4 Takenaka, Prasolava, Wang, Mortin-Toth, Khalouei, Gan (b0085) 2007; 8 Manz (b0115) 2007; 26 Brehm, Cuthbert, Yang, Miller, DiIorio, Laning (b0105) 2010; 135 Thanopoulou, Cashman, Kakagianne, Eaves, Zoumbos, Eaves (b0270) 2004; 103 Waskow, Madan, Bartels, Costa, Blasig, Rodewald (b0380) 2009; 6 Nicolini, Cashman, Hogge, Humphries, Eaves (b0285) 2004; 18 Boieri, Shah, Dressel, Inngjerdingen (b0025) 2016; 7 Adams, van der Weyden (b0035) 2008; 34 Askmyr, von Palffy, Hansen, Landberg, Hogberg, Rissler (b0340) 2017; 12 Askmyr, Agerstam, Lilljebjorn, Hansen, Karlsson, von Palffy (b0335) 2014; 4 Song, Rongvaux, Taylor, Jiang, Tebaldi, Balasubramanian (b0180) 2019; 10 Papaemmanuil, Gerstung, Bullinger, Gaidzik, Paschka, Roberts (b0205) 2016; 374 Yu, Borsotti, Schickel, Zhu, Strowig, Eynon (b0355) 2017; 129 Cosgun, Rahmig, Mende, Reinke, Hauber, Schafer (b0370) 2014; 15 Hosur, Low, Avery, Shultz, Wiles (b0040) 2017; 118 Rongvaux, Willinger, Takizawa, Rathinam, Auerbach, Murphy (b0130) 2011; 108 Bosma, Custer, Bosma (b0080) 1983; 301 Roman, Smith, Appleton, Crouch, Kelly, Kinsey (b0185) 2016; 42 Mendelson, Frenette (b0280) 2014; 20 Laurenti, Gottgens (b0005) 2018; 553 Rongvaux, Takizawa, Strowig, Willinger, Eynon, Flavell (b0060) 2013; 31 Rahmig, Kronstein-Wiedemann, Fohgrub, Kronstein, Nevmerzhitskaya, Bornhauser (b0375) 2016; 7 Martin, Welch, Uy, Fehniger, Kulkarni, Duncavage (b0260) 2010; 24 Willinger, Rongvaux, Strowig, Manz, Flavell (b0120) 2011; 32 Billerbeck, Barry, Mu, Dorner, Rice, Ploss (b0145) 2011; 117 Rhyasen, Wunderlich, Tohyama, Garcia-Manero, Mulloy, Starczynowski (b0265) 2014; 28 Herndler-Brandstetter, Shan, Yao, Stecher, Plajer, Lietzenmayer (b0175) 2017; 114 Du, Li, Sipple, Pang (b0215) 2011; 117 Reinisch, Thomas, Corces, Zhang, Gratzinger, Hong (b0295) 2016; 22 Willinger, Rongvaux, Takizawa, Yancopoulos, Valenzuela, Murphy (b0135) 2011; 108 Papaemmanuil, Gerstung, Malcovati, Tauro, Gundem, Van Loo (b0235) 2013; 122 Dohner, Weisdorf, Bloomfield (b0200) 2015; 373 Benito, Bryant, Loken, Sale, Nash, John Gass (b0275) 2003; 27 Yurino, Takenaka, Yamauchi, Nunomura, Uehara, Jinnouchi (b0385) 2016; 7 Eisterer, Jiang, Christ, Glimm, Lee, Pang (b0325) 2005; 19 Yamauchi, Takenaka, Urata, Shima, Kikushige, Tokuyama (b0095) 2013; 121 Coughlan, Harmon, Whelan, O'Brien, O'Reilly, Crotty (b0150) 2016; 25 Asfaha, Dubeykovskiy, Tomita, Yang, Stokes, Shibata (b0360) 2013; 144 Shultz (10.1016/j.bcp.2020.113794_b0070) 2014; 2014 Krevvata (10.1016/j.bcp.2020.113794_b0210) 2018; 103 Zhang (10.1016/j.bcp.2020.113794_b0320) 2010; 17 Ito (10.1016/j.bcp.2020.113794_b0110) 2012; 9 Mendelson (10.1016/j.bcp.2020.113794_b0280) 2014; 20 Pearson (10.1016/j.bcp.2020.113794_b0065) 2008 Padron (10.1016/j.bcp.2020.113794_b0310) 2015; 22 Rathinam (10.1016/j.bcp.2020.113794_b0125) 2011; 118 Enciso (10.1016/j.bcp.2020.113794_b0020) 2015; 6 Wunderlich (10.1016/j.bcp.2020.113794_b0140) 2010; 24 Abarrategi (10.1016/j.bcp.2020.113794_b0300) 2017; 127 Saito (10.1016/j.bcp.2020.113794_b0170) 2016 Muguruma (10.1016/j.bcp.2020.113794_b0255) 2011; 96 Rhyasen (10.1016/j.bcp.2020.113794_b0265) 2014; 28 Herndler-Brandstetter (10.1016/j.bcp.2020.113794_b0175) 2017; 114 Dohner (10.1016/j.bcp.2020.113794_b0200) 2015; 373 Hosur (10.1016/j.bcp.2020.113794_b0040) 2017; 118 Takenaka (10.1016/j.bcp.2020.113794_b0085) 2007; 8 Waskow (10.1016/j.bcp.2020.113794_b0380) 2009; 6 Rieger (10.1016/j.bcp.2020.113794_b0010) 2012; 4 Bosma (10.1016/j.bcp.2020.113794_b0080) 1983; 301 Boieri (10.1016/j.bcp.2020.113794_b0025) 2016; 7 Benito (10.1016/j.bcp.2020.113794_b0275) 2003; 27 Nicolini (10.1016/j.bcp.2020.113794_b0285) 2004; 18 Coughlan (10.1016/j.bcp.2020.113794_b0150) 2016; 25 Rongvaux (10.1016/j.bcp.2020.113794_b0165) 2014; 32 Cazzola (10.1016/j.bcp.2020.113794_b0240) 2013; 122 Chen (10.1016/j.bcp.2020.113794_b0390) 2017; 9 Rongvaux (10.1016/j.bcp.2020.113794_b0060) 2013; 31 Wei (10.1016/j.bcp.2020.113794_b0015) 2018; 48 Arber (10.1016/j.bcp.2020.113794_b0195) 2016; 127 Billerbeck (10.1016/j.bcp.2020.113794_b0145) 2011; 117 Thanopoulou (10.1016/j.bcp.2020.113794_b0270) 2004; 103 Wang (10.1016/j.bcp.2020.113794_b0330) 1998; 91 Bryce (10.1016/j.bcp.2020.113794_b0155) 2016; 138 Leonard (10.1016/j.bcp.2020.113794_b0190) 2017; 35 Rahmig (10.1016/j.bcp.2020.113794_b0375) 2016; 7 Leon (10.1016/j.bcp.2020.113794_b0030) 2016; 101 Zhang (10.1016/j.bcp.2020.113794_b0350) 2017; 1 Willinger (10.1016/j.bcp.2020.113794_b0135) 2011; 108 Locatelli (10.1016/j.bcp.2020.113794_b0315) 2015; 125 Askmyr (10.1016/j.bcp.2020.113794_b0340) 2017; 12 Yamauchi (10.1016/j.bcp.2020.113794_b0095) 2013; 121 Sippel (10.1016/j.bcp.2020.113794_b0160) 2019; 3 Zhang (10.1016/j.bcp.2020.113794_b0100) 2009; 13 Prochazka (10.1016/j.bcp.2020.113794_b0075) 1992; 89 Haferlach (10.1016/j.bcp.2020.113794_b0225) 1996; 87 Drexler (10.1016/j.bcp.2020.113794_b0250) 2009; 33 Martin (10.1016/j.bcp.2020.113794_b0260) 2010; 24 Asfaha (10.1016/j.bcp.2020.113794_b0360) 2013; 144 Brehm (10.1016/j.bcp.2020.113794_b0105) 2010; 135 Askmyr (10.1016/j.bcp.2020.113794_b0335) 2014; 4 Adams (10.1016/j.bcp.2020.113794_b0035) 2008; 34 Sontakke (10.1016/j.bcp.2020.113794_b0305) 2016; 2016 Shultz (10.1016/j.bcp.2020.113794_b0045) 2005; 174 Rongvaux (10.1016/j.bcp.2020.113794_b0130) 2011; 108 Eisterer (10.1016/j.bcp.2020.113794_b0325) 2005; 19 Cosgun (10.1016/j.bcp.2020.113794_b0370) 2014; 15 Du (10.1016/j.bcp.2020.113794_b0215) 2011; 117 Song (10.1016/j.bcp.2020.113794_b0180) 2019; 10 Medyouf (10.1016/j.bcp.2020.113794_b0290) 2014; 14 Yoshimi (10.1016/j.bcp.2020.113794_b0345) 2017; 130 Yu (10.1016/j.bcp.2020.113794_b0355) 2017; 129 Ito (10.1016/j.bcp.2020.113794_b0050) 2002; 100 McIntosh (10.1016/j.bcp.2020.113794_b0365) 2015; 4 Yurino (10.1016/j.bcp.2020.113794_b0385) 2016; 7 Manz (10.1016/j.bcp.2020.113794_b0115) 2007; 26 Ramsey (10.1016/j.bcp.2020.113794_b0230) 2018; 8 Tohyama (10.1016/j.bcp.2020.113794_b0245) 1994; 87 Shultz (10.1016/j.bcp.2020.113794_b0055) 2012; 12 Willinger (10.1016/j.bcp.2020.113794_b0120) 2011; 32 Papaemmanuil (10.1016/j.bcp.2020.113794_b0235) 2013; 122 Reinisch (10.1016/j.bcp.2020.113794_b0295) 2016; 22 Laurenti (10.1016/j.bcp.2020.113794_b0005) 2018; 553 Roman (10.1016/j.bcp.2020.113794_b0185) 2016; 42 Kwong (10.1016/j.bcp.2020.113794_b0090) 2014; 143 Ellegast (10.1016/j.bcp.2020.113794_b0220) 2016; 128 Papaemmanuil (10.1016/j.bcp.2020.113794_b0205) 2016; 374 |
| References_xml | – volume: 1 start-page: 972 year: 2017 end-page: 979 ident: b0350 article-title: Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines publication-title: Blood Adv. – volume: 13 start-page: 1043 year: 2009 end-page: 1058 ident: b0100 article-title: Mouse models with human immunity and their application in biomedical research publication-title: J. Cell Mol. Med. – volume: 553 start-page: 418 year: 2018 end-page: 426 ident: b0005 article-title: From haematopoietic stem cells to complex differentiation landscapes publication-title: Nature – volume: 24 start-page: 1785 year: 2010 end-page: 1788 ident: b0140 article-title: AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3 publication-title: Leukemia – volume: 103 start-page: 959 year: 2018 end-page: 971 ident: b0210 article-title: Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells publication-title: Haematologica – volume: 8 start-page: 1313 year: 2007 end-page: 1323 ident: b0085 article-title: Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells publication-title: Nat. Immunol. – volume: 122 start-page: 3616 year: 2013 end-page: 3627 ident: b0235 article-title: Clinical and biological implications of driver mutations in myelodysplastic syndromes publication-title: Blood – volume: 24 start-page: 1662 year: 2010 end-page: 1664 ident: b0260 article-title: Limited engraftment of low-risk myelodysplastic syndrome cells in NOD/SCID gamma-C chain knockout mice publication-title: Leukemia – volume: 118 start-page: 3119 year: 2011 end-page: 3128 ident: b0125 article-title: Efficient differentiation and function of human macrophages in humanized CSF-1 mice publication-title: Blood – volume: 127 start-page: 2391 year: 2016 end-page: 2405 ident: b0195 article-title: The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia publication-title: Blood – volume: 127 start-page: 543 year: 2017 end-page: 548 ident: b0300 article-title: Versatile humanized niche model enables study of normal and malignant human hematopoiesis publication-title: J. Clin. Invest. – volume: 48 start-page: 632 year: 2018 end-page: 648 ident: b0015 article-title: Niches for hematopoietic stem cells and their progeny publication-title: Immunity – volume: 18 start-page: 341 year: 2004 end-page: 347 ident: b0285 article-title: NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration publication-title: Leukemia – volume: 14 start-page: 824 year: 2014 end-page: 837 ident: b0290 article-title: Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit publication-title: Cell Stem Cell – volume: 118 start-page: 3043 year: 2017 end-page: 3048 ident: b0040 article-title: Development of humanized mice in the age of genome editing publication-title: J. Cell. Biochem. – volume: 117 start-page: 4243 year: 2011 end-page: 4252 ident: b0215 article-title: Overexpression of IL-3Ralpha on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML publication-title: Blood – volume: 96 start-page: 543 year: 2011 end-page: 551 ident: b0255 article-title: Establishment of a xenograft model of human myelodysplastic syndromes publication-title: Haematologica – volume: 7 start-page: 333 year: 2016 ident: b0025 article-title: The role of animal models in the study of hematopoietic stem cell transplantation and GvHD: a historical overview publication-title: Front. Immunol. – volume: 12 start-page: 786 year: 2012 end-page: 798 ident: b0055 article-title: Humanized mice for immune system investigation: progress, promise and challenges publication-title: Nat. Rev. Immunol. – volume: 26 start-page: 537 year: 2007 end-page: 541 ident: b0115 article-title: Human-hemato-lymphoid-system mice: opportunities and challenges publication-title: Immunity – volume: 114 start-page: E9626 year: 2017 end-page: E9634 ident: b0175 article-title: Humanized mouse model supports development, function, and tissue residency of human natural killer cells publication-title: Proc. Natl. Acad. Sci. U S A. – volume: 117 start-page: 3076 year: 2011 end-page: 3086 ident: b0145 article-title: Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2Rgamma(null) humanized mice publication-title: Blood – volume: 6 start-page: 290 year: 2015 ident: b0020 article-title: Normal vs. malignant hematopoiesis: the complexity of acute leukemia through systems biology publication-title: Front. Genet. – volume: 7 start-page: 425 year: 2016 end-page: 438 ident: b0385 article-title: Enhanced reconstitution of human erythropoiesis and thrombopoiesis in an immunodeficient mouse model with Kit(Wv) mutations publication-title: Stem Cell Rep. – volume: 28 start-page: 1142 year: 2014 end-page: 1145 ident: b0265 article-title: An MDS xenograft model utilizing a patient-derived cell line publication-title: Leukemia – volume: 25 start-page: 530 year: 2016 end-page: 541 ident: b0150 article-title: Myeloid engraftment in humanized mice: impact of granulocyte-colony stimulating factor treatment and transgenic mouse strain publication-title: Stem Cells Dev. – volume: 20 start-page: 833 year: 2014 end-page: 846 ident: b0280 article-title: Hematopoietic stem cell niche maintenance during homeostasis and regeneration publication-title: Nat. Med. – volume: 7 start-page: 591 year: 2016 end-page: 601 ident: b0375 article-title: Improved human erythropoiesis and platelet formation in humanized NSGW41 Mice publication-title: Stem Cell Rep. – year: 2008 ident: b0065 article-title: Creation of “humanized” mice to study human immunity publication-title: Curr. Protoc. Immunol. – volume: 32 start-page: 364 year: 2014 end-page: 372 ident: b0165 article-title: Development and function of human innate immune cells in a humanized mouse model publication-title: Nat. Biotechnol. – volume: 128 start-page: 2130 year: 2016 end-page: 2134 ident: b0220 article-title: inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice publication-title: Blood – volume: 8 start-page: 1566 year: 2018 end-page: 1581 ident: b0230 article-title: A novel MCL1 inhibitor combined with venetoclax rescues venetoclax-resistant acute myelogenous leukemia publication-title: Cancer Disc. – year: 2016 ident: b0170 article-title: Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice publication-title: Blood – volume: 42 start-page: 186 year: 2016 end-page: 198 ident: b0185 article-title: Myeloid malignancies in the real-world: occurrence, progression and survival in the UK's population-based Haematological Malignancy Research Network 2004–15 publication-title: Cancer Epidemiol. – volume: 135 start-page: 84 year: 2010 end-page: 98 ident: b0105 article-title: Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation publication-title: Clin. Immunol. – volume: 374 start-page: 2209 year: 2016 end-page: 2221 ident: b0205 article-title: Genomic classification and prognosis in acute myeloid leukemia publication-title: N. Engl. J. Med. – volume: 174 start-page: 6477 year: 2005 end-page: 6489 ident: b0045 article-title: Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells publication-title: J. Immunol. – volume: 87 start-page: 235 year: 1994 end-page: 242 ident: b0245 article-title: Establishment and characterization of a novel myeloid cell line from the bone marrow of a patient with the myelodysplastic syndrome publication-title: Br. J. Haematol. – volume: 34 start-page: 225 year: 2008 end-page: 238 ident: b0035 article-title: Contemporary approaches for modifying the mouse genome publication-title: Physiol. Genomics – volume: 4 year: 2012 ident: b0010 article-title: Hematopoiesis publication-title: Cold Spring Harb. Perspect. Biol. – volume: 22 start-page: 812 year: 2016 end-page: 821 ident: b0295 article-title: A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells publication-title: Nat. Med. – volume: 373 start-page: 1136 year: 2015 end-page: 1152 ident: b0200 article-title: Acute myeloid leukemia publication-title: N. Engl. J. Med. – volume: 130 start-page: 397 year: 2017 end-page: 407 ident: b0345 article-title: Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML publication-title: Blood – volume: 22 start-page: 163 year: 2015 end-page: 170 ident: b0310 article-title: Cutting the cord from myelodysplastic syndromes: chronic myelomonocytic leukemia-specific biology and management strategies publication-title: Curr. Opin. Hematol. – volume: 143 start-page: 61 year: 2014 end-page: 67 ident: b0090 article-title: Signal-regulatory protein alpha from the NOD mouse binds human CD47 with an exceptionally high affinity– implications for engraftment of human cells publication-title: Immunology – volume: 2014 start-page: 694 year: 2014 end-page: 708 ident: b0070 article-title: Human cancer growth and therapy in immunodeficient mouse models publication-title: Cold Spring Harb. Protoc. – volume: 31 start-page: 635 year: 2013 end-page: 674 ident: b0060 article-title: Human hemato-lymphoid system mice: current use and future potential for medicine publication-title: Annu. Rev. Immunol. – volume: 301 start-page: 527 year: 1983 end-page: 530 ident: b0080 article-title: A severe combined immunodeficiency mutation in the mouse publication-title: Nature – volume: 138 start-page: 769 year: 2016 end-page: 779 ident: b0155 article-title: Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis publication-title: J. Allergy Clin. Immunol. – volume: 33 start-page: 1011 year: 2009 end-page: 1016 ident: b0250 article-title: Many are called MDS cell lines: one is chosen publication-title: Leuk. Res. – volume: 108 start-page: 2390 year: 2011 end-page: 2395 ident: b0135 article-title: Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung publication-title: Proc. Natl. Acad. Sci. U S A. – volume: 87 start-page: 2459 year: 1996 end-page: 2463 ident: b0225 article-title: The abnormal eosinophils are part of the leukemic cell population in acute myelomonocytic leukemia with abnormal eosinophils (AML M4Eo) and carry the pericentric inversion 16: a combination of May-Grunwald-Giemsa staining and fluorescence in situ hybridization publication-title: Blood – volume: 103 start-page: 4285 year: 2004 end-page: 4293 ident: b0270 article-title: Engraftment of NOD/SCID-beta2 microglobulin null mice with multilineage neoplastic cells from patients with myelodysplastic syndrome publication-title: Blood – volume: 15 start-page: 227 year: 2014 end-page: 238 ident: b0370 article-title: Kit regulates HSC engraftment across the human-mouse species barrier publication-title: Cell Stem Cell – volume: 19 start-page: 435 year: 2005 end-page: 441 ident: b0325 article-title: Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease publication-title: Leukemia – volume: 4 start-page: 171 year: 2015 end-page: 180 ident: b0365 article-title: Nonirradiated NOD, B6.SCID Il2rgamma-/- Kit(W41/W41) (NBSGW) mice support multilineage engraftment of human hematopoietic cells publication-title: Stem Cell Rep. – volume: 32 start-page: 321 year: 2011 end-page: 327 ident: b0120 article-title: Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement publication-title: Trends Immunol. – volume: 3 start-page: 268 year: 2019 end-page: 274 ident: b0160 article-title: Human hematopoietic stem cell maintenance and myeloid cell development in next-generation humanized mouse models publication-title: Blood Adv. – volume: 125 start-page: 1083 year: 2015 end-page: 1090 ident: b0315 article-title: How I treat juvenile myelomonocytic leukemia publication-title: Blood – volume: 12 year: 2017 ident: b0340 article-title: Transgenic expression of human cytokines in immunodeficient mice does not facilitate myeloid expansion of BCR-ABL1 transduced human cord blood cells publication-title: PLoS ONE – volume: 10 start-page: 366 year: 2019 ident: b0180 article-title: A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies publication-title: Nat. Commun. – volume: 4 year: 2014 ident: b0335 article-title: Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells publication-title: Blood Cancer J. – volume: 6 start-page: 267 year: 2009 end-page: 269 ident: b0380 article-title: Hematopoietic stem cell transplantation without irradiation publication-title: Nat. Methods – volume: 108 start-page: 2378 year: 2011 end-page: 2383 ident: b0130 article-title: Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo publication-title: Proc. Natl. Acad. Sci. U S A. – volume: 2016 start-page: 1625015 year: 2016 ident: b0305 article-title: Modeling of chronic myeloid leukemia: an overview of in vivo murine and human xenograft models publication-title: Stem Cells Int. – volume: 100 start-page: 3175 year: 2002 end-page: 3182 ident: b0050 article-title: NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells publication-title: Blood – volume: 35 start-page: 2708 year: 2017 end-page: 2715 ident: b0190 article-title: Practical implications of the 2016 revision of the World Health Organization classification of lymphoid and myeloid neoplasms and acute leukemia publication-title: J. Clin. Oncol. – volume: 9 start-page: 208 year: 2012 end-page: 214 ident: b0110 article-title: Current advances in humanized mouse models publication-title: Cell. Mol. Immunol. – volume: 129 start-page: 959 year: 2017 end-page: 969 ident: b0355 article-title: A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production publication-title: Blood – volume: 9 start-page: 1034 year: 2017 end-page: 1042 ident: b0390 article-title: Complement depletion improves human red blood cell reconstitution in immunodeficient mice publication-title: Stem Cell Rep. – volume: 89 start-page: 3290 year: 1992 end-page: 3294 ident: b0075 article-title: The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency publication-title: Proc. Natl. Acad. Sci. U S A. – volume: 121 start-page: 1316 year: 2013 end-page: 1325 ident: b0095 article-title: Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment publication-title: Blood – volume: 91 start-page: 2406 year: 1998 end-page: 2414 ident: b0330 article-title: High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase publication-title: Blood – volume: 27 start-page: 425 year: 2003 end-page: 436 ident: b0275 article-title: NOD/SCID mice transplanted with marrow from patients with myelodysplastic syndrome (MDS) show long-term propagation of normal but not clonal human precursors publication-title: Leuk. Res. – volume: 17 start-page: 427 year: 2010 end-page: 442 ident: b0320 article-title: Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate publication-title: Cancer Cell – volume: 144 start-page: 155 year: 2013 end-page: 166 ident: b0360 article-title: Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis publication-title: Gastroenterology – volume: 122 start-page: 4021 year: 2013 end-page: 4034 ident: b0240 article-title: The genetic basis of myelodysplasia and its clinical relevance publication-title: Blood – volume: 101 start-page: 896 year: 2016 end-page: 908 ident: b0030 article-title: The contribution of mouse models to the understanding of constitutional thrombocytopenia publication-title: Haematologica – volume: 14 start-page: 824 year: 2014 ident: 10.1016/j.bcp.2020.113794_b0290 article-title: Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit publication-title: Cell Stem Cell doi: 10.1016/j.stem.2014.02.014 – volume: 4 start-page: 171 year: 2015 ident: 10.1016/j.bcp.2020.113794_b0365 article-title: Nonirradiated NOD, B6.SCID Il2rgamma-/- Kit(W41/W41) (NBSGW) mice support multilineage engraftment of human hematopoietic cells publication-title: Stem Cell Rep. doi: 10.1016/j.stemcr.2014.12.005 – volume: 12 year: 2017 ident: 10.1016/j.bcp.2020.113794_b0340 article-title: Transgenic expression of human cytokines in immunodeficient mice does not facilitate myeloid expansion of BCR-ABL1 transduced human cord blood cells publication-title: PLoS ONE doi: 10.1371/journal.pone.0186035 – volume: 301 start-page: 527 year: 1983 ident: 10.1016/j.bcp.2020.113794_b0080 article-title: A severe combined immunodeficiency mutation in the mouse publication-title: Nature doi: 10.1038/301527a0 – volume: 138 start-page: 769 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0155 article-title: Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2016.01.049 – volume: 87 start-page: 2459 year: 1996 ident: 10.1016/j.bcp.2020.113794_b0225 publication-title: Blood doi: 10.1182/blood.V87.6.2459.bloodjournal8762459 – volume: 108 start-page: 2390 year: 2011 ident: 10.1016/j.bcp.2020.113794_b0135 article-title: Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung publication-title: Proc. Natl. Acad. Sci. U S A. doi: 10.1073/pnas.1019682108 – volume: 27 start-page: 425 year: 2003 ident: 10.1016/j.bcp.2020.113794_b0275 article-title: NOD/SCID mice transplanted with marrow from patients with myelodysplastic syndrome (MDS) show long-term propagation of normal but not clonal human precursors publication-title: Leuk. Res. doi: 10.1016/S0145-2126(02)00221-7 – volume: 32 start-page: 364 year: 2014 ident: 10.1016/j.bcp.2020.113794_b0165 article-title: Development and function of human innate immune cells in a humanized mouse model publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2858 – volume: 100 start-page: 3175 year: 2002 ident: 10.1016/j.bcp.2020.113794_b0050 article-title: NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells publication-title: Blood doi: 10.1182/blood-2001-12-0207 – year: 2008 ident: 10.1016/j.bcp.2020.113794_b0065 article-title: Creation of “humanized” mice to study human immunity publication-title: Curr. Protoc. Immunol. doi: 10.1002/0471142735.im1521s81 – volume: 10 start-page: 366 year: 2019 ident: 10.1016/j.bcp.2020.113794_b0180 article-title: A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies publication-title: Nat. Commun. doi: 10.1038/s41467-018-08166-x – volume: 20 start-page: 833 year: 2014 ident: 10.1016/j.bcp.2020.113794_b0280 article-title: Hematopoietic stem cell niche maintenance during homeostasis and regeneration publication-title: Nat. Med. doi: 10.1038/nm.3647 – volume: 22 start-page: 163 year: 2015 ident: 10.1016/j.bcp.2020.113794_b0310 article-title: Cutting the cord from myelodysplastic syndromes: chronic myelomonocytic leukemia-specific biology and management strategies publication-title: Curr. Opin. Hematol. doi: 10.1097/MOH.0000000000000112 – volume: 24 start-page: 1662 year: 2010 ident: 10.1016/j.bcp.2020.113794_b0260 article-title: Limited engraftment of low-risk myelodysplastic syndrome cells in NOD/SCID gamma-C chain knockout mice publication-title: Leukemia doi: 10.1038/leu.2010.156 – volume: 174 start-page: 6477 year: 2005 ident: 10.1016/j.bcp.2020.113794_b0045 article-title: Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells publication-title: J. Immunol. doi: 10.4049/jimmunol.174.10.6477 – volume: 128 start-page: 2130 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0220 article-title: inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice publication-title: Blood doi: 10.1182/blood-2015-12-689356 – volume: 33 start-page: 1011 year: 2009 ident: 10.1016/j.bcp.2020.113794_b0250 article-title: Many are called MDS cell lines: one is chosen publication-title: Leuk. Res. doi: 10.1016/j.leukres.2009.03.005 – volume: 8 start-page: 1313 year: 2007 ident: 10.1016/j.bcp.2020.113794_b0085 article-title: Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells publication-title: Nat. Immunol. doi: 10.1038/ni1527 – volume: 117 start-page: 4243 year: 2011 ident: 10.1016/j.bcp.2020.113794_b0215 article-title: Overexpression of IL-3Ralpha on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML publication-title: Blood doi: 10.1182/blood-2010-09-309179 – volume: 18 start-page: 341 year: 2004 ident: 10.1016/j.bcp.2020.113794_b0285 article-title: NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration publication-title: Leukemia doi: 10.1038/sj.leu.2403222 – volume: 7 start-page: 333 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0025 article-title: The role of animal models in the study of hematopoietic stem cell transplantation and GvHD: a historical overview publication-title: Front. Immunol. doi: 10.3389/fimmu.2016.00333 – volume: 89 start-page: 3290 year: 1992 ident: 10.1016/j.bcp.2020.113794_b0075 article-title: The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency publication-title: Proc. Natl. Acad. Sci. U S A. doi: 10.1073/pnas.89.8.3290 – volume: 6 start-page: 267 year: 2009 ident: 10.1016/j.bcp.2020.113794_b0380 article-title: Hematopoietic stem cell transplantation without irradiation publication-title: Nat. Methods doi: 10.1038/nmeth.1309 – volume: 135 start-page: 84 year: 2010 ident: 10.1016/j.bcp.2020.113794_b0105 article-title: Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation publication-title: Clin. Immunol. doi: 10.1016/j.clim.2009.12.008 – volume: 24 start-page: 1785 year: 2010 ident: 10.1016/j.bcp.2020.113794_b0140 article-title: AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3 publication-title: Leukemia doi: 10.1038/leu.2010.158 – volume: 19 start-page: 435 year: 2005 ident: 10.1016/j.bcp.2020.113794_b0325 article-title: Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease publication-title: Leukemia doi: 10.1038/sj.leu.2403649 – volume: 1 start-page: 972 year: 2017 ident: 10.1016/j.bcp.2020.113794_b0350 article-title: Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines publication-title: Blood Adv. doi: 10.1182/bloodadvances.2017004903 – volume: 25 start-page: 530 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0150 article-title: Myeloid engraftment in humanized mice: impact of granulocyte-colony stimulating factor treatment and transgenic mouse strain publication-title: Stem Cells Dev. doi: 10.1089/scd.2015.0289 – volume: 22 start-page: 812 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0295 article-title: A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells publication-title: Nat. Med. doi: 10.1038/nm.4103 – volume: 130 start-page: 397 year: 2017 ident: 10.1016/j.bcp.2020.113794_b0345 article-title: Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML publication-title: Blood doi: 10.1182/blood-2017-01-763219 – volume: 48 start-page: 632 year: 2018 ident: 10.1016/j.bcp.2020.113794_b0015 article-title: Niches for hematopoietic stem cells and their progeny publication-title: Immunity doi: 10.1016/j.immuni.2018.03.024 – volume: 35 start-page: 2708 year: 2017 ident: 10.1016/j.bcp.2020.113794_b0190 article-title: Practical implications of the 2016 revision of the World Health Organization classification of lymphoid and myeloid neoplasms and acute leukemia publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2017.72.6745 – volume: 118 start-page: 3043 year: 2017 ident: 10.1016/j.bcp.2020.113794_b0040 article-title: Development of humanized mice in the age of genome editing publication-title: J. Cell. Biochem. doi: 10.1002/jcb.26002 – volume: 117 start-page: 3076 year: 2011 ident: 10.1016/j.bcp.2020.113794_b0145 article-title: Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2Rgamma(null) humanized mice publication-title: Blood doi: 10.1182/blood-2010-08-301507 – volume: 31 start-page: 635 year: 2013 ident: 10.1016/j.bcp.2020.113794_b0060 article-title: Human hemato-lymphoid system mice: current use and future potential for medicine publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-032712-095921 – volume: 143 start-page: 61 year: 2014 ident: 10.1016/j.bcp.2020.113794_b0090 article-title: Signal-regulatory protein alpha from the NOD mouse binds human CD47 with an exceptionally high affinity– implications for engraftment of human cells publication-title: Immunology doi: 10.1111/imm.12290 – volume: 103 start-page: 959 year: 2018 ident: 10.1016/j.bcp.2020.113794_b0210 article-title: Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells publication-title: Haematologica doi: 10.3324/haematol.2017.183202 – volume: 4 year: 2012 ident: 10.1016/j.bcp.2020.113794_b0010 article-title: Hematopoiesis publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a008250 – volume: 108 start-page: 2378 year: 2011 ident: 10.1016/j.bcp.2020.113794_b0130 article-title: Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo publication-title: Proc. Natl. Acad. Sci. U S A. doi: 10.1073/pnas.1019524108 – volume: 129 start-page: 959 year: 2017 ident: 10.1016/j.bcp.2020.113794_b0355 article-title: A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production publication-title: Blood doi: 10.1182/blood-2016-04-709584 – volume: 87 start-page: 235 year: 1994 ident: 10.1016/j.bcp.2020.113794_b0245 article-title: Establishment and characterization of a novel myeloid cell line from the bone marrow of a patient with the myelodysplastic syndrome publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.1994.tb04904.x – volume: 127 start-page: 543 year: 2017 ident: 10.1016/j.bcp.2020.113794_b0300 article-title: Versatile humanized niche model enables study of normal and malignant human hematopoiesis publication-title: J. Clin. Invest. doi: 10.1172/JCI89364 – volume: 122 start-page: 3616 year: 2013 ident: 10.1016/j.bcp.2020.113794_b0235 article-title: Clinical and biological implications of driver mutations in myelodysplastic syndromes publication-title: Blood doi: 10.1182/blood-2013-08-518886 – volume: 553 start-page: 418 year: 2018 ident: 10.1016/j.bcp.2020.113794_b0005 article-title: From haematopoietic stem cells to complex differentiation landscapes publication-title: Nature doi: 10.1038/nature25022 – volume: 2014 start-page: 694 year: 2014 ident: 10.1016/j.bcp.2020.113794_b0070 article-title: Human cancer growth and therapy in immunodeficient mouse models publication-title: Cold Spring Harb. Protoc. doi: 10.1101/pdb.top073585 – volume: 103 start-page: 4285 year: 2004 ident: 10.1016/j.bcp.2020.113794_b0270 article-title: Engraftment of NOD/SCID-beta2 microglobulin null mice with multilineage neoplastic cells from patients with myelodysplastic syndrome publication-title: Blood doi: 10.1182/blood-2003-09-3192 – volume: 127 start-page: 2391 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0195 article-title: The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia publication-title: Blood doi: 10.1182/blood-2016-03-643544 – volume: 8 start-page: 1566 year: 2018 ident: 10.1016/j.bcp.2020.113794_b0230 article-title: A novel MCL1 inhibitor combined with venetoclax rescues venetoclax-resistant acute myelogenous leukemia publication-title: Cancer Disc. doi: 10.1158/2159-8290.CD-18-0140 – volume: 12 start-page: 786 year: 2012 ident: 10.1016/j.bcp.2020.113794_b0055 article-title: Humanized mice for immune system investigation: progress, promise and challenges publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3311 – volume: 2016 start-page: 1625015 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0305 article-title: Modeling of chronic myeloid leukemia: an overview of in vivo murine and human xenograft models publication-title: Stem Cells Int. doi: 10.1155/2016/1625015 – volume: 28 start-page: 1142 year: 2014 ident: 10.1016/j.bcp.2020.113794_b0265 article-title: An MDS xenograft model utilizing a patient-derived cell line publication-title: Leukemia doi: 10.1038/leu.2013.372 – volume: 3 start-page: 268 year: 2019 ident: 10.1016/j.bcp.2020.113794_b0160 article-title: Human hematopoietic stem cell maintenance and myeloid cell development in next-generation humanized mouse models publication-title: Blood Adv. doi: 10.1182/bloodadvances.2018023887 – volume: 17 start-page: 427 year: 2010 ident: 10.1016/j.bcp.2020.113794_b0320 article-title: Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.03.011 – volume: 6 start-page: 290 year: 2015 ident: 10.1016/j.bcp.2020.113794_b0020 article-title: Normal vs. malignant hematopoiesis: the complexity of acute leukemia through systems biology publication-title: Front. Genet. doi: 10.3389/fgene.2015.00290 – volume: 101 start-page: 896 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0030 article-title: The contribution of mouse models to the understanding of constitutional thrombocytopenia publication-title: Haematologica doi: 10.3324/haematol.2015.139394 – volume: 114 start-page: E9626 year: 2017 ident: 10.1016/j.bcp.2020.113794_b0175 article-title: Humanized mouse model supports development, function, and tissue residency of human natural killer cells publication-title: Proc. Natl. Acad. Sci. U S A. doi: 10.1073/pnas.1705301114 – volume: 125 start-page: 1083 year: 2015 ident: 10.1016/j.bcp.2020.113794_b0315 article-title: How I treat juvenile myelomonocytic leukemia publication-title: Blood doi: 10.1182/blood-2014-08-550483 – volume: 144 start-page: 155 year: 2013 ident: 10.1016/j.bcp.2020.113794_b0360 article-title: Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis publication-title: Gastroenterology doi: 10.1053/j.gastro.2012.09.057 – volume: 7 start-page: 425 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0385 article-title: Enhanced reconstitution of human erythropoiesis and thrombopoiesis in an immunodeficient mouse model with Kit(Wv) mutations publication-title: Stem Cell Rep. doi: 10.1016/j.stemcr.2016.07.002 – volume: 373 start-page: 1136 year: 2015 ident: 10.1016/j.bcp.2020.113794_b0200 article-title: Acute myeloid leukemia publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra1406184 – volume: 26 start-page: 537 year: 2007 ident: 10.1016/j.bcp.2020.113794_b0115 article-title: Human-hemato-lymphoid-system mice: opportunities and challenges publication-title: Immunity doi: 10.1016/j.immuni.2007.05.001 – volume: 374 start-page: 2209 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0205 article-title: Genomic classification and prognosis in acute myeloid leukemia publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1516192 – volume: 121 start-page: 1316 year: 2013 ident: 10.1016/j.bcp.2020.113794_b0095 article-title: Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment publication-title: Blood doi: 10.1182/blood-2012-06-440354 – volume: 96 start-page: 543 year: 2011 ident: 10.1016/j.bcp.2020.113794_b0255 article-title: Establishment of a xenograft model of human myelodysplastic syndromes publication-title: Haematologica doi: 10.3324/haematol.2010.027557 – volume: 32 start-page: 321 year: 2011 ident: 10.1016/j.bcp.2020.113794_b0120 article-title: Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement publication-title: Trends Immunol. doi: 10.1016/j.it.2011.04.005 – volume: 15 start-page: 227 year: 2014 ident: 10.1016/j.bcp.2020.113794_b0370 article-title: Kit regulates HSC engraftment across the human-mouse species barrier publication-title: Cell Stem Cell doi: 10.1016/j.stem.2014.06.001 – volume: 13 start-page: 1043 year: 2009 ident: 10.1016/j.bcp.2020.113794_b0100 article-title: Mouse models with human immunity and their application in biomedical research publication-title: J. Cell Mol. Med. doi: 10.1111/j.1582-4934.2008.00347.x – volume: 4 year: 2014 ident: 10.1016/j.bcp.2020.113794_b0335 article-title: Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells publication-title: Blood Cancer J. doi: 10.1038/bcj.2014.89 – volume: 34 start-page: 225 year: 2008 ident: 10.1016/j.bcp.2020.113794_b0035 article-title: Contemporary approaches for modifying the mouse genome publication-title: Physiol. Genomics doi: 10.1152/physiolgenomics.90242.2008 – year: 2016 ident: 10.1016/j.bcp.2020.113794_b0170 article-title: Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice publication-title: Blood doi: 10.1182/blood-2015-10-676452 – volume: 9 start-page: 208 year: 2012 ident: 10.1016/j.bcp.2020.113794_b0110 article-title: Current advances in humanized mouse models publication-title: Cell. Mol. Immunol. doi: 10.1038/cmi.2012.2 – volume: 122 start-page: 4021 year: 2013 ident: 10.1016/j.bcp.2020.113794_b0240 article-title: The genetic basis of myelodysplasia and its clinical relevance publication-title: Blood doi: 10.1182/blood-2013-09-381665 – volume: 42 start-page: 186 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0185 article-title: Myeloid malignancies in the real-world: occurrence, progression and survival in the UK's population-based Haematological Malignancy Research Network 2004–15 publication-title: Cancer Epidemiol. doi: 10.1016/j.canep.2016.03.011 – volume: 9 start-page: 1034 year: 2017 ident: 10.1016/j.bcp.2020.113794_b0390 article-title: Complement depletion improves human red blood cell reconstitution in immunodeficient mice publication-title: Stem Cell Rep. doi: 10.1016/j.stemcr.2017.08.018 – volume: 118 start-page: 3119 year: 2011 ident: 10.1016/j.bcp.2020.113794_b0125 article-title: Efficient differentiation and function of human macrophages in humanized CSF-1 mice publication-title: Blood doi: 10.1182/blood-2010-12-326926 – volume: 91 start-page: 2406 year: 1998 ident: 10.1016/j.bcp.2020.113794_b0330 article-title: High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase publication-title: Blood doi: 10.1182/blood.V91.7.2406 – volume: 7 start-page: 591 year: 2016 ident: 10.1016/j.bcp.2020.113794_b0375 article-title: Improved human erythropoiesis and platelet formation in humanized NSGW41 Mice publication-title: Stem Cell Rep. doi: 10.1016/j.stemcr.2016.08.005 |
| SSID | ssj0006861 |
| Score | 2.3885512 |
| SecondaryResourceType | review_article |
| Snippet | [Display omitted]
Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect... Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 113794 |
| SubjectTerms | Cytokine humanization Humanized mice Immunodeficient mouse models Myeloid malignancy Pre-clinical studies Xenotransplantation |
| Title | Humanized mice as preclinical models for myeloid malignancies |
| URI | https://dx.doi.org/10.1016/j.bcp.2020.113794 https://www.ncbi.nlm.nih.gov/pubmed/31926939 https://www.proquest.com/docview/2337071384 |
| Volume | 174 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwELYQDLAgKO9HZSTEgAgkjuPYI6pABaSqA5W6WX4FFUFbkTKUgd_OOU6oGGBgTHRWnO_O9p18dx9CpxnjQkOYEOWZzSPqlI7AOVIRTZR2YB-pC90-e6w7oPfDbLiEOk0tjE-rrPf-sKdXu3X95qpG82o6Gvka35gRAf4D2KkP83wFO829lV9-LtI8GGc1ax6LvHRzs1nleGnjW1aSitkkF_S3s-k337M6g2430HrtPOLrML9NtOTGLbTaaTjbWuisHzpRzy_w46KwqrzAZ7i_6FE930KBlGL04Sz2fPRYlXgKONRlkrjixykxOLT4de5eJiMQA4f9KXD5lttocHvz2OlGNZNCZGgiZpEtCFGc0IIaHhe5yCy1rMhVEmtmhTAFhMiqSDJrUgbA55oUQqca1ifXPDUu3UHL48nY7SHMmCaJMloIx2isiDaAObWKw1rm1pp9FDcYSlO3GfdsFy-yySd7lgC79LDLAPs-Ov8eMg09Nv4Spo1i5A9DkXAG_DXspFGiBJ34WxE1dpP3UpI0zX2ozkFmN2j3exbwT4SJVBz876OHaM0_hUSfI7Q8e3t3x-DDzHS7MtI2Wrm-e-j2vgD_gu7e |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VcigXRMurQMFI0ANq2sRxHPvAARWqLS1VD1upN-NX0KJ2d0W2QsuBP9U_2HHsdMWhPSD1mtiJ881kPJPMzAfwruJCGgwTsrpydca8Nhk6RzpjhTYe9aP0sdvnER-csK-n1ekSXPa1MCGtMtn-aNM7a52O7CQ0d6ajUajxzTmV6D-gnoYwL2VWHvj5b4zb2o_7n1HI7ynd-zLcHWSJWiCzrJCzzDWUakFZw6zIm1pWjjne1LrIDXdS2gZjRt0UlbMlx5XUhjbSlAYVVhhRWl_ide_BfYbmItAmbP9d5JVwwRNNH8_C8vpfqV1SmbGhRybtqFRqyW7aDG9ydrtNb-8RPEzeKvkUAVmFJT9eg5XdniRuDTaPY-vr-RYZLiq52i2ySY4XTbHnjyGyYIz-eEfO0TYR3ZIpAp_qMklHyNMS9KDJ-dyfTUY4DCOEH5E8uH0CJ3eC71NYHk_G_jkQzg0ttDVSes5yTY1lNWdOCzQewjm7DnmPobKpr3mg1zhTfQLbT4WwqwC7irCvw4frKdPY1OO2wawXjPpHMxVuOrdNe9sLUaFMwm8YPfaTi1bRsqzDtwGBY55F6V6vAp-JclnKF_930zewMhh-O1SH-0cHL-FBOBOzjF7B8uzXhd9AB2pmXncKS-D7Xb8hV4FwK_c |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Humanized+mice+as+preclinical+models+for+myeloid+malignancies&rft.jtitle=Biochemical+pharmacology&rft.au=Gbyli%2C+Rana&rft.au=Song%2C+Yuanbin&rft.au=Halene%2C+Stephanie&rft.date=2020-04-01&rft.issn=0006-2952&rft.volume=174&rft.spage=113794&rft_id=info:doi/10.1016%2Fj.bcp.2020.113794&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_bcp_2020_113794 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0006-2952&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0006-2952&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0006-2952&client=summon |