Why does GM1 induce a potent beneficial response to experimental Chagas disease?

Being one of the world's neglected diseases, Chagas has neither a vaccine nor a satisfactory therapy. Inoculation of murine models with the ganglioside GM1 has shown a strikingly nonlinear effect, leading to a strong decrease in parasite load at low doses but reverting to a load increase at hig...

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Published inHFSP Journal Vol. 3; no. 2; pp. 142 - 151
Main Authors Isasi, S. Cossy, Condat, C. A., Sibona, G. J.
Format Journal Article
LanguageEnglish
Published France Taylor & Francis Group 01.04.2009
HFSP Publishing
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Summary:Being one of the world's neglected diseases, Chagas has neither a vaccine nor a satisfactory therapy. Inoculation of murine models with the ganglioside GM1 has shown a strikingly nonlinear effect, leading to a strong decrease in parasite load at low doses but reverting to a load increase at high doses. Cardiocyte destruction concomitant with the disease is also significantly reduced by a moderate application of GM1. A mathematical model for the interaction between the parasite and the immune system is shown to explain these effects and is used to predict an optimal dosage that maximizes parasite removal with minimal cardiocyte destruction.
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ISSN:1955-2068
1955-205X
DOI:10.2976/1.3067922