Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with type 1 diabetes in Croatians

• Published in: Diabetes research and clinical practice Vol. 86; no. 3; pp. e54 - e57
• Main Authors: Korolija, Marina, Renar, Ivana Pavlić, Hadžija, Mirko, Medvidović, Edita Pape, Pavković, Pajica, Jokić, Mladen, Hadžija, Marijana Popović
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.12.2009
• Subjects: Adenine; Adult; Age of Onset; Antigens, CD - genetics; Blood Glucose - analysis; Croatia; CTLA-4; CTLA-4 Antigen; Cytosine; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - genetics; DNA Primers; Endocrinology & Metabolism; Genetic Variation; Genotype; Glycated Hemoglobin A - analysis; Guanine; Humans; Polymerase Chain Reaction; Polymorphism; Polymorphism, Genetic; Polymorphism, Single Nucleotide; PTPN22; Reference Values; Risk Assessment; Thymine; Type 1 diabetes; PTPN22; CTLA-4; Type 1 diabetes; Polymorphism
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2009.09.012

Abstract In this case–control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient ( n = 102) and control ( n = 193) groups differ significantly ( p < 0.0001 and p = 0.012, respectively). Moreover, although the risk alleles of both SNPs are distributed more frequently in patients, the significant difference is observed only for PTPN22 1858T allele ( p < 0.0001). This is therefore the first evidence that analyzed gene variants contribute to T1D pathogenesis in Croatian population.