Behavioral Maintenance of High Concentrations of Blood Ethanol and Physical Dependence in the Rat

Rats maintained on an intermittent food schedule with an available ethanol solution drink to excess (13.1 grams of ethanol per kilogram of body weight, daily). Removal of ethanol produces symptoms of physical dependence including death from tonic-clonic seizures. Overindulgence in oral self-administ...

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Published inScience (American Association for the Advancement of Science) Vol. 177; no. 4051; pp. 811 - 813
Main Authors Falk, John L., Samson, Herman H., Winger, Gail
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 01.09.1972
Subjects
Alcohol Drinking
Alcoholism
Animal models
Animals
Body weight
Disease Models, Animal
Drinking Behavior
Ethanol
Ethanol - blood
Food availability
Humans
Male
Neurites
Polydipsia
Rats
Rats, Inbred Strains
Substance Withdrawal Syndrome
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Summary:Rats maintained on an intermittent food schedule with an available ethanol solution drink to excess (13.1 grams of ethanol per kilogram of body weight, daily). Removal of ethanol produces symptoms of physical dependence including death from tonic-clonic seizures. Overindulgence in oral self-administration of an aqueous ethanol solution, resulting in unequivocal physical dependence, approximates a model of human alcoholism.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.177.4051.811