The cellular mechanisms that maintain neuronal polarity

• Published in: Nature reviews. Neuroscience Vol. 17; no. 10; pp. 611 - 622
• Main Authors: Bentley, Marvin, Banker, Gary
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.10.2016
• Subjects: Animals; Axons; Axons - metabolism; Cell Polarity; Cell regulation; Dendrites; Dendrites - metabolism; Genetic aspects; Humans; Membrane proteins; Membrane Proteins - metabolism; Membranes; Nerve Tissue Proteins - metabolism; Neurons - cytology; Neurons - metabolism; Polarity (Biology); Properties; Protein Transport; Proteins; Psychological aspects; Oregon; United States > US

As polarized cells, neurons maintain different sets of resident plasma membrane proteins in their axons and dendrites, which is consistent with the different roles that these neurites have in electrochemical signalling. Axonal and dendritic proteins are synthesized together within the somatodendriti...