Preclinical safety evaluation of the ethanolic extract from guavira fruits (Campomanesia pubescens (D.C.) O. BERG) in experimental models of acute and short-term toxicity in rats

• Published in: Food and chemical toxicology Vol. 118; pp. 1 - 12
• Main Authors: Villas Boas, Gustavo Roberto, Carvalho dos Santos, Ariany, Carvalho Souza, Roosevelt Isaias, Souza de Araújo, Flávio Henrique, Traesel, Giseli Karenina, Marcelino, Jhony Moreira, Stefanello da Silveira, Ana Paula, Feitosa Farinelli, Brunna Charlla, Lima Cardoso, Claudia Andréa, Boerngen de Lacerda, Roseli, Oesterreich, Silvia Aparecida
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2018
• Subjects: Acute toxicity; Campomanesia pubescens; LD50; Preclinical studies; Repeated doses; Safety; UDP; Preclinical studies; MCV; AST; RDW; ALT; CNS; UFGD; Repeated doses; LD50; HDL; MCH; OECD; Campomanesia pubescens; MCHC; Safety; Acute toxicity; EEFCP; WHO; LD
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2018.04.063

Campomanesia pubescens is a fruit plant widely distributed in South America and used by the population for medicinal and nutritional purposes, with important economic and cultural value. This study evaluated the toxic potential of the ethanolic extract from C. pubescens (EEFCP) fruits through acute and short-term toxicity tests. For the acute toxicity test, female rats received a single oral dose of 2000 mg/kg body weight of EEFCP and were observed for 14 days. In the short-term toxicity test, male and female rats received repeated oral doses of 125, 250, 500 or 1000 mg/kg of EEFCP, being treated and observed for 28 days, and after the treatment period, a satellite and satellite control group remained under observation for another 14 days. No mortality, clinical and organ weight alterations were observed, indicating that LD50 is greater than 2000 mg/kg body weight. In addition, the doses tested did not produce significant changes in the behavioral, physiological, hematological or histopathological parameters of animals. These results demonstrate the low acute and short-term toxicity of EEFCP in rats. The data obtained are of great relevance since they provide important information about a plant species of great economic, nutritional and ethnopharmacological value. •The ethanolic extract from C. pubescens fruits is safe for human consumption in high doses.