Triple HIV-1 Infection

To the Editor: Dual infection with different strains of HIV type 1 (HIV-1) is reported with increasing frequency, attributed mostly to coinfection at the time of the primary infection. However, some patients were superinfected with a second virus after the original seroconversion, 1 which generally...

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Published inThe New England journal of medicine Vol. 352; no. 24; pp. 2557 - 2559
Main Authors van der Kuyl, Antoinette C, Kozaczynska, Karolina, van den Burg, Remco, Zorgdrager, Fokla, Back, Nicole, Jurriaans, Suzanne, Berkhout, Ben, Reiss, Peter, Cornelissen, Marion
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 16.06.2005
Subjects
Adult
CD4 Lymphocyte Count
Genes, env
Genes, gag
Genotype
HIV Infections - virology
HIV-1 - genetics
Humans
Male
Phylogeny
Superinfection - virology
Unsafe Sex
Viral Load
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Summary:To the Editor: Dual infection with different strains of HIV type 1 (HIV-1) is reported with increasing frequency, attributed mostly to coinfection at the time of the primary infection. However, some patients were superinfected with a second virus after the original seroconversion, 1 which generally accelerated disease progression. 2 We encountered a case of serial HIV-1 superinfection resulting in a triple infection in a Dutch patient who was originally infected with a subtype B virus. A 35-year-old homosexual man was found to be HIV-1–seropositive in March 2001 and was referred for follow-up. Early in July 2003, the patient presented with acute onset . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM200506163522420