Intrauterine infection, magnesium sulfate exposure and cerebral palsy in infants born between 26 and 30 weeks of gestation

• Published in: European journal of obstetrics & gynecology and reproductive biology Vol. 91; no. 2; pp. 159 - 164
• Main Authors: Matsuda, Yoshio, Kouno, Satoshi, Hiroyama, Yoshifumi, Kuraya, Kazue, Kamitomo, Masato, Ibara, Satoshi, Hatae, Masayuki
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.08.2000; Elsevier
• Subjects: Abruptio Placentae - complications; Adolescent; Adult; Biological and medical sciences; Birth Weight; Case-Control Studies; Cerebral palsy; Cerebral Palsy - etiology; Delivery. Postpartum. Lactation; Disorders; Female; Fetal Membranes, Premature Rupture - complications; Gestational Age; Gynecology. Andrology. Obstetrics; Heart Rate, Fetal; Humans; Intrauterine infection; Logistic Models; Magnesium sulfate; Magnesium Sulfate - administration & dosage; Maternal Age; Medical sciences; Pregnancy; Pregnancy Complications, Infectious; Pregnancy, High-Risk; Risk Factors; Uterine Diseases - complications; Cerebral palsy; Magnesium sulfate; Intrauterine infection; Gestational age; Human; Nervous system diseases; Toxicity; Case control study; In utero; Maternal treatment; Cerebral disorder; Infection; Newborn; Prematurity; Central nervous system disease; Risk factor; Fetus
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/S0301-2115(99)00256-0

Objective: To identify prenatal events associated with cerebral palsy (CP) in infants born between 26 and 30 weeks of gestation. Study Design: Case (n=22)–control (n=170) study was performed using a logistic regression model. Results: Significant association of intrauterine infection with increased risk of CP was found in a logistic regression model that controlled for abnormal FHR patterns, placental infection, fetal acidosis at birth (umbilical artery pH<7.1), and low Apgar score (<7) (odds ratio (OR) 5.47, 95% confidence interval (CI) 1.46–20.4). Magnesium sulfate exposure was associated with decreased risk (OR 0.13, CI 0.03–0.66) after exclusion of premature rupture of the membranes and abruptio placentae. In the magnesium exposure group, cases were infants born less than 28 weeks of gestation (3/21 vs. 0/61, P=0.015). Conclusion: In this case–control study, both intrauterine infection and magnesium sulfate exposure were significant factors related to the occurrence of cerebral palsy.