The role of NLRP3 inflammasome in digestive system malignancy

Digestive system malignancies, the most common types of cancer and a major cause of death in the worldwide, are generally characterized by high morbidity, insidious symptoms and poor prognosis. NLRP3 inflammasome, the most studied inflammasome member, is considered to be crucial in tumorigenesis. In...

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Published inFrontiers in cell and developmental biology Vol. 10; p. 1051612
Main Authors Sun, Cen-Cen, Li, Li, Tao, Hou-Quan, Jiang, Zhi-Chen, Wang, Liang, Wang, Hui-Ju
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 23.12.2022
Subjects
anti-tumorigenic
Cell and Developmental Biology
digestive system malignancy
inflammasome
NLRP3
pro-tumorigenic
digestive system malignancy
pro-tumorigenic
NLRP3
anti-tumorigenic
inflammasome
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Summary:Digestive system malignancies, the most common types of cancer and a major cause of death in the worldwide, are generally characterized by high morbidity, insidious symptoms and poor prognosis. NLRP3 inflammasome, the most studied inflammasome member, is considered to be crucial in tumorigenesis. In this paper, we reviewed its pro-tumorigenic and anti-tumorigenic properties in different types of digestive system malignancy depending on the types of cells, tissues and organs involved, which would provide promising avenue for exploring new anti-cancer therapies.
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Reviewed by: Balaji Banoth, St. Jude Children's Research Hospital, United States
These authors have contributed equally to this work
Fan Xin, Affiliated Hospital of Jiangsu University, China
Edited by: Zhi-Gang Zhang, Shanghai Jiao Tong University, China
This article was submitted to Cancer Cell Biology, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.1051612