Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years

• Published in: Journal of clinical and diagnostic research Vol. 10; no. 4; pp. EC15 - EC17
• Main Authors: Kanodia, Kamal V, Vanikar, Aruna V, Patel, Rashmi D, Suthar, Kamlesh S, Nigam, Lovelesh K, Patel, Himanshu V, Kute, Vivek, Trivedi, Hargovind L
• Format: Journal Article
• Language: English
• Published: India JCDR Research and Publications Private Limited 01.04.2016
• Subjects: end stage renal disease; idiopathic collapsing glomerulopathy; podocyte; proteinuria; Podocyte; End stage renal disease; Idiopathic collapsing glomerulopathy; Proteinuria
• ISSN: 2249-782X; 0973-709X
• DOI: 10.7860/JCDR/2016/17297.7646

Collapsing Glomerulopathy (CG) is recognized as distinct pattern of proliferative parenchymal injury with poor response to empirical therapy. A single center retrospective study was carried out to find out clinicopathological features of idiopathic CG. A total of 3335 native renal biopsies were analyzed retrospectively which were performed from 2008 to 2014 with emphasis on clinicopathological correlation and histopathological presentation. Idiopathic CG constituted 0.75% incidence (25 out of 3335 biopsies) of all biopsies, adults constituting major study part with 88%. The duration of the symptoms at the time of biopsy was 34.12±26.09 days and 35±22.91 days respectively in adults and children. Hypertension was noted in 9(40.9%) and oliguria in 8(36.4%) in adults. Urinalysis revealed microscopic haematuria 12(54.5%) in adults. Nephrotic range proteinuria was reported in 10 (45.5%) adult patients. Glomerular collapse with hyperplasia/ hypertrophy of podocytes was seen in 4.54±3.11 glomeruli. Tubular microcystic dilation was seen in 16(64%) patients. Tubular atrophy involving mild (t1) in 15(60%), moderate (t2) in 4(16%) and severe (t3) in 6(24%) patients. Interstitial fibrosis was mild (i1) in 17(68%), moderate (i2) in 2(8%) and severe (i3) in 6(24%) patients. Idiopathic CG is a morphological pattern of grave podocyte injury with poor prognosis. However, there are chances of remission/ recovery if the tubular atrophy and interstitial fibrosis are of grades ≤ t1 i1.