Dimethylbenzanthracene Tumorigenesis and Aryl Hydrocarbon Hydroxylase in Mouse Skin: Inhibition by 7,8-Benzoflavone

Mouse skin contains aryl hydrocarbon hydroxylase which is highly inducible. The enzyme system is inhibited when 7,8-benzoflavone is added to homogenates of skin epidermis. 7,8-Benzoflavone also inhibits mouse skin tumorigenesis caused by repeated treatment with 9,10-dimethylbenzanthracene or by a si...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 170; no. 3954; pp. 169 - 171
Main Authors Gelboin, Harry V., Wiebel, Friedrich, Diamond, Leila
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 09.10.1970
Subjects
Animals
Benz(a)Anthracenes - antagonists & inhibitors
Carcinogens
Cell Transformation, Neoplastic
Croton Oil
Cyclic hydrocarbons
Enzymes
Epidermis
Flavones
Flavonoids - pharmacology
Hydrocarbons
Liver
Mice
Mixed Function Oxygenases - antagonists & inhibitors
Naphthalenes - metabolism
Neoplasms, Experimental - chemically induced
Polycyclic compounds
Skin
Skin - enzymology
Skin Neoplasms - chemically induced
Skin Neoplasms - drug therapy
Tumors
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Summary:Mouse skin contains aryl hydrocarbon hydroxylase which is highly inducible. The enzyme system is inhibited when 7,8-benzoflavone is added to homogenates of skin epidermis. 7,8-Benzoflavone also inhibits mouse skin tumorigenesis caused by repeated treatment with 9,10-dimethylbenzanthracene or by a single treatment with this chemical followed by weekly treatment with croton oil. These findings suggest that this enzyme system may be responsible for the activation of 9,10-dimethylbenzanthracene to its carcinogenic form.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.170.3954.169