Dimethylbenzanthracene Tumorigenesis and Aryl Hydrocarbon Hydroxylase in Mouse Skin: Inhibition by 7,8-Benzoflavone
Mouse skin contains aryl hydrocarbon hydroxylase which is highly inducible. The enzyme system is inhibited when 7,8-benzoflavone is added to homogenates of skin epidermis. 7,8-Benzoflavone also inhibits mouse skin tumorigenesis caused by repeated treatment with 9,10-dimethylbenzanthracene or by a si...
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Published in | Science (American Association for the Advancement of Science) Vol. 170; no. 3954; pp. 169 - 171 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
American Association for the Advancement of Science
09.10.1970
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Subjects | |
Online Access | Get full text |
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Summary: | Mouse skin contains aryl hydrocarbon hydroxylase which is highly inducible. The enzyme system is inhibited when 7,8-benzoflavone is added to homogenates of skin epidermis. 7,8-Benzoflavone also inhibits mouse skin tumorigenesis caused by repeated treatment with 9,10-dimethylbenzanthracene or by a single treatment with this chemical followed by weekly treatment with croton oil. These findings suggest that this enzyme system may be responsible for the activation of 9,10-dimethylbenzanthracene to its carcinogenic form. |
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ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.170.3954.169 |