A comparative phylogenomic analysis of peste des petits ruminants virus isolated from wild and unusual hosts

• Published in: Molecular biology reports Vol. 46; no. 5; pp. 5587 - 5593
• Main Authors: Rahman, Aziz-ul, Munir, Muhammad, Shabbir, Muhammad Zubair
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.10.2019; Springer Nature B.V
• Subjects: Animal Anatomy; Animal Biochemistry; Animals; Animals, Domestic - genetics; Animals, Wild - genetics; Biomedical and Life Sciences; Comparative analysis; Developing countries; Disease resistance; Epidemiology; Excretion; Histology; Host Microbial Interactions; Immune response; LDCs; Life Sciences; Livestock; Molecular Epidemiology - methods; Morphology; Peste des petits ruminants; Peste-des-Petits-Ruminants - genetics; Peste-des-Petits-Ruminants - virology; Peste-des-petits-ruminants virus - genetics; Peste-des-petits-ruminants virus - pathogenicity; Phylogeny; Short Communication; Strains (organisms); Molecular epidemiology; Phylogenomic analysis; Peste des petits ruminants virus; Wild and unusual hosts; Residue comparison
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-019-04973-7

Peste des petits ruminants virus (PPRV) infects a wide range of domestic and wild ruminants, and occasionally unusual hosts such as camel, cattle and pig. Given their broad host-spectrum and disease endemicity in several developing countries, it is imperative to elucidate the viral evolutionary insights for their dynamic pathobiology and differential host-selection. For this purpose, a dataset of all available (n = 37) PPRV sequences originating from wild and unusual hosts was composed and in silico analysed. Compared to domestic small ruminant strains of same geographical region, phylogenomic and residue analysis of PPRV sequences originating from wild and unusual hosts revealed a close relationship between strains. A lack of obvious difference among the studied sequences and deduced residues suggests that these are the host factors that may play a role in their susceptibility to PPRV infection, immune response, pathogenesis, excretion patterns and potential clinical signs or resistance to clinical disease. Summarizing together, the comparative analysis enhances our understanding towards molecular epidemiology of the PPRV in wild and unusual hosts for appropriate intervention strategies particularly at livestock-wildlife interface.