Synthesis and Properties of Ag-doped Titanium-10 wt% 45S5 Bioglass Nanostructured Scaffolds

• Published in: Acta metallurgica sinica : English letters Vol. 28; no. 4; pp. 467 - 476
• Main Authors: Jurczyk, K., Miklaszewski, A., Niespodziana, K., Kubicka, M., Jurczyk, M. U., Jurczyk, M.
• Format: Journal Article
• Language: English
• Published: Heidelberg The Chinese Society for Metals 01.04.2015; Springer Nature B.V
• Subjects: Bacteria; Bacterial corrosion; Biocompatibility; Bioglass; Characterization and Evaluation of Materials; Chemistry and Materials Science; Composite materials; Contact angle; Corrosion and Coatings; Corrosion resistance; Corrosion tests; Cytotoxicity; Dentistry; Diamond pyramid hardness; In vitro methods and tests; Materials Science; Metallic Materials; Morphology; Nanocomposites; Nanostructure; Nanotechnology; Organometallic Chemistry; Porosity; Powder metallurgy; Prostheses; Scaffolds; Silver; Software; Spectroscopy/Spectrometry; Surgical implants; Titanium; Titanium alloys; Transplants & implants; Tribology; 多孔钛; 性能; 掺银; 支架材料; 生物玻璃; 纳米复合材料; 重量; 金黄色葡萄球菌; Titanium; 45S5 Bioglass; Nanocrystalline materials; Biomaterials
• ISSN: 1006-7191; 2194-1289
• DOI: 10.1007/s40195-015-0221-0

A new kind of biomedical Ti-45S5 Bioglass-Ag nanocomposites and their scaffolds with antibacterial function was developed by the introduction of 1.5 wt% Ag into the Ti-10 wt% 45S5 Bioglass matrix. The microstructure, hardness and corrosion resistance in Ringer solution of the Ag-doped Ti-45S5 glass were investigated. The Vickers hardness of the bulk Ti-10 wt% 45S5 Bioglass-1.5 wt% Ag nanocomposites reached 480 HVo.3. Contact angles of water on the micro- crystalline Ti and nanostructured Ti-10 wt% 45S5 Bioglass-1.5 wt% Ag sample were determined and show visible decrease from 55.2° to 49.6°. In vitro tests culture of normal human osteoblast cells showed very good cells proliferation, colonization and multilayering. In vitro bacterial adhesion study indicated a significantly reduced number of bacteria （Staphylococcus aureus） on the bulk nanostructured Ti-10 wt% 45S5 Bioglass-1.5 wt% Ag plate surface in comparison with that on microcrystalline Ti plate surface. Development of porous Ti-10 wt% 45S5 Bioglass-1.5 wt% Ag scaffolds aims in enhancing bone ingrowth and prosthesis fixation.